C1C992

PR
Gene name
tilS
Protein name
tRNA(Ile)-lysidine synthase
Names
tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase
Species
Streptococcus pneumoniae (strain 70585)
KEGG Pathway
snm:SP70585_0011
EC number
6.3.4.19: Other carbon--nitrogen ligases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

307-384 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C1C992

Entry ID Method Resolution Chain Position Source
AF-C1C992-F1 Predicted AlphaFoldDB

No variants for C1C992

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C1C992

No associated diseases with C1C992

3 regional properties for C1C992

Type Name Position InterPro Accession
domain tRNA(Ile)-lysidine/2-thiocytidine synthase, N-terminal 22 - 190 IPR011063
domain tRNA(Ile)-lysidine synthase, N-terminal 21 - 194 IPR012795
domain Lysidine-tRNA(Ile) synthetase, C-terminal 348 - 415 IPR012796

Functions

Description
EC Number 6.3.4.19 Other carbon--nitrogen ligases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ligase activity, forming carbon-nitrogen bonds Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.

1 GO annotations of biological process

Name Definition
tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MREPDFLNHF LKKGYFKKHA KAVLALSGGL DSMFLFKVLS TYQKELEIEL ILAHVNHKQR
70 80 90 100 110 120
IESDWEEKEL RKLAAEAELP IYISNFSGEF SEARARNFRY DFFQEVMKKT GATALVTAHH
130 140 150 160 170 180
ADDQVETIFM RLIRGTRLRY LSGIKEKQVV GEIEIIRPFL HFQKKDFPSI FHFEDTSNQE
190 200 210 220 230 240
NHYFRNRIRN SYLPELEKEN PRFRDAILGI GNEILDYDLA IAELSNNINV EDLQQLFSYS
250 260 270 280 290 300
ESTQRVLLQT YLNRFPDLNL TKAQFAEVQQ ILKSKSQYRH PIKNGYELIK EYQQFQICKI
310 320 330 340 350 360
SPQADEEEDE LVLHYQNQVA YQGYLFSFGL PLEGESIQQI PVSRETSIHI RHRKTGDVLI
370 380 390 400 410 420
QNGHRKKLRR LFIDLKIPME KRNSALIIEQ FGEIVSILGI ATNNLSKKTK NDIMNTVLYI
EKIDR