C0Z9X2

PR
Gene name
cysI
Protein name
Sulfite reductase [NADPH] hemoprotein beta-component
Names
SiR-HP, SiRHP
Species
Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
KEGG Pathway
bbe:BBR47_58490
EC number
1.8.1.2: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-101 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C0Z9X2

Entry ID Method Resolution Chain Position Source
AF-C0Z9X2-F1 Predicted AlphaFoldDB

No variants for C0Z9X2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C0Z9X2

No associated diseases with C0Z9X2

5 regional properties for C0Z9X2

Type Name Position InterPro Accession
domain Nitrite/Sulfite reductase ferredoxin-like domain 76 - 138 IPR005117-1
domain Nitrite/Sulfite reductase ferredoxin-like domain 355 - 420 IPR005117-2
binding_site Nitrite/sulphite reductase iron-sulphur/sirohaem-binding site 433 - 451 IPR006066-1
binding_site Nitrite/sulphite reductase iron-sulphur/sirohaem-binding site 481 - 499 IPR006066-2
domain Nitrite/sulphite reductase 4Fe-4S domain 171 - 332 IPR006067

Functions

Description
EC Number 1.8.1.2 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
sulfite reductase complex (NADPH) A multisubunit iron flavoprotein, which in yeast is composed of 2 alpha and 2 beta subunits. Catalyzes the reduction of sulfite to sulfide.

5 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
metal ion binding Binding to a metal ion.
NADP binding Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
sulfite reductase (NADPH) activity Catalysis of the reaction: hydrogen sulfide + 3 NADP+ + 3 H2O = sulfite + 3 NADPH + 3 H+.

3 GO annotations of biological process

Name Definition
cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid.
hydrogen sulfide biosynthetic process The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S.
sulfate assimilation The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSENHLLSSN SAPHSDVEDI KRKSDYLRGS LAETLEDRIS GSIPEDDNRL MKFHGSYMQD
70 80 90 100 110 120
DRDLRNERSK QKLEPAYQFM VRVRAAGGVV TPEQWLMMDD IAQQFANGTI RLTTRQSFQL
130 140 150 160 170 180
HGVIKWNMKQ VIQEVNEALL STLAACGDVN RNVMCNPNPY ESEVHQEVYE WAKKISNHLD
190 200 210 220 230 240
PRTRAYHEIW LDEEKVVDSR DEVEQEPIYG PVYLPRKFKI GIAVPPANDV DVFSQDLGFI
250 260 270 280 290 300
AIHEEGRLLG FNVAVGGGMG MTHGDPKTYP QVARVIGFVT PEQVLEVAEK TVMIQRDYGD
310 320 330 340 350 360
RAVRKHARFK YTIDDRGIEW FIHELEQRLG WELEQVRPYH FEHNGDRYGW VKGSDDNWHF
370 380 390 400 410 420
TLFIQNGRVK DEDNYLLKSG LREIAKVHTG DFRLTPNQNL LIGNVTSEKK PEIEQIIQAY
430 440 450 460 470 480
GLTDGATYSA LRRNSMACVS LPTCGLAMAE AERYLPTLLD EIELILDEAG LRDEEIVIRM
490 500 510 520 530 540
TGCPNGCARP ALAEISFIGK AVGKYNMYLG GGFSGNRLNK LYRENIGEAE ILNELRPILN
550 560 570
RYAKEREEGE HFGDFVIRAG YVKEVRSGLD FHE