C0SJS2

PR
Gene name
CYP71AJ3
Protein name
Psoralen synthase
Names
Cytochrome P450 CYP71AJ3
Species
Pastinaca sativa (Wild parsnip) (Anethum pastinaca)
KEGG Pathway
EC number
1.14.14.141: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-61 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C0SJS2

Entry ID Method Resolution Chain Position Source
AF-C0SJS2-F1 Predicted AlphaFoldDB

No variants for C0SJS2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C0SJS2

No associated diseases with C0SJS2

1 regional properties for C0SJS2

Type Name Position InterPro Accession
conserved_site Cytochrome P450, conserved site 418 - 427 IPR017972

Functions

Description
EC Number 1.14.14.141 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Subcellular Localization
  • Microsome membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
iron ion binding Binding to an iron (Fe) ion.
psoralen synthase activity Catalysis of the reaction: (+)-marmesin + NADPH + H+ + O2 <=> psoralen + NADP + acetone + 2 H2O.

2 GO annotations of biological process

Name Definition
coumarin biosynthetic process The chemical reactions and pathways resulting in the formation of coumarins, a class of compounds derived from the phenylacrylic skeleton of cinnamic acids.
response to wounding Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
YFFPLFLVTI FLYKWLVKKT PSKNLPPSPP RLPIIGNLHQ IGPDPQISLR DLAREYGPVM
70 80 90 100 110 120
HLKFGSVPVL VVSSADGARE IFKTHDLVFA DRPYSSVANR IFYNGRDMVF ARYTEYWRQV
130 140 150 160 170 180
KSTCVTQLLS VKRVQSFHNV REEEVALLLD NIENSKSKVI NLSEMLIELT GNVVCRAALG
190 200 210 220 230 240
SGYNVDSYKS LLLQIMDMLG YSRSIEDFFP SLGWVDWITG LKGKVEKAAN GVDAFLEGVL
250 260 270 280 290 300
KNHTNPSTSS ANKDFVSILL EIQEADAGSS MDKECIKSLI WDMLGAGTET IATALEWTIG
310 320 330 340 350 360
ALIKSPDAMS KLQKEVREIG KGKSRIEEGD LVKMDYLKAV MKESMRLYFT APLLVPREAR
370 380 390 400 410 420
QDVKFMGYDI KSGTQVLINA WAIARDPSSW DNPEEFRPER FLNSPIDYKG FNYEYIPFGA
430 440 450 460 470
GRRGCPGIQF AISVNELVVA NVVNKFNFEL PDGKRLEEMD MTASTGITFH KKS