C0RW22

PR
Gene name
CDK14 (PFTK1)
Protein name
Cyclin-dependent kinase 14
Names
Cell division protein kinase 14
Species
Dasypus novemcinctus (Nine-banded armadillo)
KEGG Pathway
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

29-145 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

272-295 (Activation loop from InterPro)

Target domain

134-418 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for C0RW22

Entry ID Method Resolution Chain Position Source
AF-C0RW22-F1 Predicted AlphaFoldDB

No variants for C0RW22

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C0RW22

No associated diseases with C0RW22

3 regional properties for C0RW22

Type Name Position InterPro Accession
domain Protein kinase domain 134 - 418 IPR000719
active_site Serine/threonine-protein kinase, active site 251 - 263 IPR008271
binding_site Protein kinase, ATP binding site 140 - 163 IPR017441

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein
  • Cytoplasm
  • Nucleus
  • Recruited to the cell membrane by CCNY
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasmic cyclin-dependent protein kinase holoenzyme complex Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

5 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
G2/M transition of mitotic cell cycle The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of canonical Wnt signaling pathway Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MCDLIEPQPA EKIGKMKKLR RTLSESFSRI ALKKEDTTFD EICVTKMSTR NCQGMDSVIK
70 80 90 100 110 120
PLDTIPEDKV RVQRTQSTFD PFEKPTNQVK RVHSENNACI NFKTSSAGKE SPKVRRHSSP
130 140 150 160 170 180
SSPTSPKFGK ADSYEKLEKL GEGSYATVYK GKSKVNGKLV ALKVIRLQEE EGTPFTAIRE
190 200 210 220 230 240
ASLLKGLKHA NIVLLHDIIH TKETLTLVFE YVHTDLCQYM DKHPGGLHPE NVKLFLFQLL
250 260 270 280 290 300
RGLSYIHQRY ILHRDLKPQN LLISDTGELK LADFGLARAK SVPSHTYSNE VVTLWYRPPD
310 320 330 340 350 360
VLLGSTEYST CLDMWGVGCI FVEMIQGVAA FPGMKDIQDQ LERIFLVLGT PNEDTWPGVH
370 380 390 400 410 420
SLPHFKPERF TLYSSKNLRQ AWNKLSYVNH AEDLASKLLQ CSPKNRLSAQ AALSHEYFSD
430 440 450 460
LPPRLWELTD MSSIFTVPNV RLQPEAGESM RAFGKNNSYG KSLSNSKH