C0R046

PR
Gene name
gyrA
Protein name
DNA gyrase subunit A
Names
Species
Brachyspira hyodysenteriae (strain ATCC 49526 / WA1)
KEGG Pathway
bhy:BHWA1_01001
EC number
5.6.2.2: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-50 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C0R046

Entry ID Method Resolution Chain Position Source
AF-C0R046-F1 Predicted AlphaFoldDB

No variants for C0R046

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C0R046

No associated diseases with C0R046

2 regional properties for C0R046

Type Name Position InterPro Accession
domain IMP dehydrogenase/GMP reductase 8 - 317 IPR001093
conserved_site IMP dehydrogenase / GMP reductase, conserved site 166 - 178 IPR015875

Functions

Description
EC Number 5.6.2.2 Enzymes altering nucleic acid conformation
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA negative supercoiling activity Catalytic introduction of negative supercoils into a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria.

2 GO annotations of biological process

Name Definition
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAVKKNKEDN SEERQYSTLT KDILKRVDHI SIENELRESY LTYAMSVIVS RALPDVRDGL
70 80 90 100 110 120
KPVHRRILYA MYDANLTHDK PYKKSAATVG EVLARYHPHG DAAVYGTMVR MAQDFSMRYL
130 140 150 160 170 180
LVDGQGNFGS IDDDPPAAMR YTEARMTRFA EEMLNDIEKE TVKFVPNFDD SRTEPSVLPA
190 200 210 220 230 240
TVPQLLVNGS MGIAIGMATN MPPHNLKEVV NAIVYYIDHQ DAEIKDLMRY VQGPDFPTAG
250 260 270 280 290 300
IIYGKEGIKE AYTTGKGRIK LRARLEVEET KRDREAIVVK ELPYGVVKTT LHEKIADLVK
310 320 330 340 350 360
QGKIEGVADI RDESSNRAGI RLIIELKKGV ATQIVLNQLW KHTDLETTFG IINLALVNGE
370 380 390 400 410 420
PKVLNLKELI KYFVDHRVEV ITKRTEYDLN QAKAKAHILE GLLIAQANIE EVIRIIRESE
430 440 450 460 470 480
NTDAARTTLM NRFKLSEKQA QAILDMPLKR LTALEKLKIE QELQQLREFI AYCEDLLAHP
490 500 510 520 530 540
EKILAVIKDE LKKISEKYGD DRRSEIIGKT NDTEIDEEDL IHDEDVAVSI TTQGFIKRVP
550 560 570 580 590 600
ASSYRTQGRG GVGVQGGKSQ GEHYIEHLFV ASTKDYLFIF TDRGKAFWMK VHEIPALSKI
610 620 630 640 650 660
SQGKSIKFIL NLAPEEKITS YFTVSEFDPK QSIIMVTKMG TIKKMELKHL ENAKKRGILA
670 680 690 700 710 720
LTLENNDELV AVSPVQTGDD FIMTTAAGLA LRITEEKIRK MGRAAAGVKG ISLDDDDICV
730 740 750 760 770 780
SGNAIHKGES LIVITENGIG KRLSSKQFNV KGRGGKGQIY IKPDNKTGNV VSVKTVGDKD
790 800 810 820 830
EIMVVTTDDM TIKIKADSIP ELGRNAKGVK IVNISDGARV SDLAVVPADN EEKK