C0QFS1

PR
Gene name
mutS
Protein name
DNA mismatch repair protein MutS
Names
Species
Desulforapulum autotrophicum (strain ATCC 43914 / DSM 3382 / VKM B-1955 / HRM2) (Desulfobacterium autotrophicum)
KEGG Pathway
dat:HRM2_23940
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

789-876 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C0QFS1

Entry ID Method Resolution Chain Position Source
AF-C0QFS1-F1 Predicted AlphaFoldDB

No variants for C0QFS1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C0QFS1

No associated diseases with C0QFS1

5 regional properties for C0QFS1

Type Name Position InterPro Accession
domain DNA mismatch repair protein MutS, C-terminal 625 - 817 IPR000432
domain DNA mismatch repair protein MutS-like, N-terminal 7 - 118 IPR007695
domain DNA mismatch repair protein MutS, core 280 - 607 IPR007696
domain DNA mismatch repair protein MutS, connector domain 127 - 261 IPR007860
domain DNA mismatch repair protein MutS, clamp 444 - 535 IPR007861

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
damaged DNA binding Binding to damaged DNA.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

1 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTVKKETPMM EQYLSIKKRY PDTILFYRMG DFYEMFLDDA LKAAPVLEIA LTSRNKTQED
70 80 90 100 110 120
PIPMCGVPHR AADVYIAKLI ESGLKVAVCE QMEDPRSAQG IVKREVVRVI TPGMILNEDL
130 140 150 160 170 180
LDKKSNNFLA ALCICQGAAG LACMDISTGM FRTTQTVAVN GKVPLSLVDE ALRIDAKELL
190 200 210 220 230 240
LPASFKGDPT YSQLIKAFET IQISYVGNEN FKLDSARERL KEKFRTRSLE GFGCEDLTAG
250 260 270 280 290 300
TAAAGAILSY VQETQLRETD HVLTLERYEL NTYLIIDDRS CRNLELLKNI QTSDKKGSLI
310 320 330 340 350 360
SVLDCTITAM GGRLLKAWIR YPLISMDGIE ARLDAVAEAK ENPGIRNSLR THLKDVYDLE
370 380 390 400 410 420
RLGSKISMGH ANPRDLTALK ISLYKLPLLF KDLNQLSASL LQGHGIEDRE KVSTELFELA
430 440 450 460 470 480
DLINQTIRED APLALNEGGI ICDGYSPELD EILEIARNGR SWIAKTGAKE KEKTGLSSLK
490 500 510 520 530 540
IKFNKVFGYF IEVSKIQSQQ VPDHYIRKQT LVNAERFITD ELKEVESKVL NAQERRSSLE
550 560 570 580 590 600
YALFCKVRES IVQRTPSIFK IAQFLAEVDV VLALATTAEE NNYTRPALNK DQVLDIEDGR
610 620 630 640 650 660
HPVVEKMVVG ERYIPNSIRL DNTSDQVQII TGPNMAGKST VLRQVALISL MAQMGSFVPA
670 680 690 700 710 720
ARADLCIIDR IFTRVGALDN LSLGQSTFMV EMEETANIVN NAKENSLVIL DEIGRGTSTF
730 740 750 760 770 780
DGMSIAWAVA EYLHDLDGKG VKTLFATHYH ELTRLEKLKP RVKNFNIAVK EFNDNIIFLR
790 800 810 820 830 840
RLVPGGTNKS YGIQVARLAG VPDAVITKAK QILASIEQSP DQVVTQDKKQ VKKQTKNNHS
850 860 870 880 890
ARSGSRQQQM DLFAGHDYDE IIKVLDQTDI STMTPIDALN LIHELKQKIR SKAMI