C0NF00

PR
Gene name
MDM12
Protein name
Mitochondrial distribution and morphology protein 12
Names
Mitochondrial inheritance component MDM12
Species
Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) (Darling's disease fungus) (Histoplasma capsulatum)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

56-132 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C0NF00

Entry ID Method Resolution Chain Position Source
AF-C0NF00-F1 Predicted AlphaFoldDB

No variants for C0NF00

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C0NF00

No associated diseases with C0NF00

1 regional properties for C0NF00

Type Name Position InterPro Accession
domain Synaptotagmin-like mitochondrial-lipid-binding domain 1 - 430 IPR031468

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion outer membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side
  • The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions
  • These foci are often found next to mtDNA nucleoids
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
ERMES complex A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles.

1 GO annotations of molecular function

Name Definition
lipid binding Binding to a lipid.

3 GO annotations of biological process

Name Definition
lipid transport The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
mitochondrial genome maintenance The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.
protein insertion into mitochondrial outer membrane The process comprising the insertion of proteins from outside the organelle into the mitochondrial outer membrane, mediated by large outer membrane translocase complexes.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSIDIDWERA TSGPDGELLA ERIRSFIHDK FQQIVLPRFI RSVQVTSFNF GTIPPELEIR
70 80 90 100 110 120
DLSDPFPDFY EDDDENFSDS SEEGSPTREP VDRYGNRVDS WQANSPGGPG GQMYESNQPL
130 140 150 160 170 180
RMPAWEEHTG ISPLRGPMNF GDINPYLFPR SGTPGIPGGT SNLGYYMPLS GLSSSQTPLG
190 200 210 220 230 240
AVARGNPFSG GWPDAHGARP SRRRSEAEPD SAQSRPSTAN TGNTLPSRDS MSISDPHHSH
250 260 270 280 290 300
ASQGMPNNQG QALEPNIPPT SPNHPLDDTP PRRMREQKAE DFQVFCRTKY AGNISLSLTA
310 320 330 340 350 360
EILLDYPMPS FVGLPLKLNI TGLTFDAVAV IAYIRRRIHF CFLSPEDADT LMGPETAGGG
370 380 390 400 410 420
GGGDTSEPNS SRRKPSSLLR EIRVESEIGR KENGKQALKN VGKLEKFVLE QVRRIFEEEF
VYPSFWTFLI