C0M7C8

PR
Gene name
rpoB
Protein name
DNA-directed RNA polymerase subunit beta
Names
RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta
Species
Streptococcus equi subsp equi (strain 4047)
KEGG Pathway
seu:SEQ_0098
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1128-1188 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C0M7C8

Entry ID Method Resolution Chain Position Source
AF-C0M7C8-F1 Predicted AlphaFoldDB

No variants for C0M7C8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C0M7C8

No associated diseases with C0M7C8

8 regional properties for C0M7C8

Type Name Position InterPro Accession
domain DNA-directed RNA polymerase, subunit 2, hybrid-binding domain 679 - 1065 IPR007120
conserved_site RNA polymerase, beta subunit, conserved site 918 - 930 IPR007121
domain RNA polymerase Rpb2, domain 7 1067 - 1141 IPR007641
domain RNA polymerase Rpb2, domain 2 140 - 290 IPR007642-1
domain RNA polymerase Rpb2, domain 2 368 - 414 IPR007642-2
domain RNA polymerase, beta subunit, protrusion 28 - 460 IPR007644
domain RNA polymerase Rpb2, domain 3 473 - 538 IPR007645
domain DNA-directed RNA polymerase, beta subunit, external 1 domain 551 - 618 IPR019462

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
ribonucleoside binding Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose.

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAGHDVQYGK HRTRRSFSRI KEVLDLPNLI EIQTDSFQDF LDSGLKEVFE DVLPISNFTD
70 80 90 100 110 120
TMELEFVGYE FKEPKYTLEE ARIHDASYSA PIFVTFRLIN KETGEIKTQE VFFGDFPIMT
130 140 150 160 170 180
EMGTFIINGG ERIIVSQLVR SPGVYFNDKV DKNGKVGYGS TVIPNRGAWL ELETDSKDIA
190 200 210 220 230 240
YTRIDRTRKI PFTTLVRALG FSGDDEIIDI FGDSELVRNT IEKDIHKNQS DSRTDEALKE
250 260 270 280 290 300
IYERLRPGEP KTADSSRSLL TARFFDARRY DLAAVGRYKI NKKLNIKTRL LNQIIAENLI
310 320 330 340 350 360
DSETGEILVE AGTEMTRSVI ESIEEQLDGD LNKFVYTPND YAVVTEPVIL QKFKVVSPVD
370 380 390 400 410 420
PDRVVTIVGN ANPDDKVRAL TPADILAEMS YFLNLAEGLG KVDDIDHLGN RRIRAVGELL
430 440 450 460 470 480
ANQFRIGLAR MERNVRERMS VQDNDVLTPQ QIINIRPVTA AVKEFFGSSQ LSQFMDQHNP
490 500 510 520 530 540
LSELSHKRRL SALGPGGLTR DRAGYEVRDV HYTHYGRMCP IETPEGPNIG LINNLSSFGH
550 560 570 580 590 600
LNKYGFIQTP YRKVDRVIGR VTNEIVWLTA DEEDEFTVAQ ANSKLNPDGT FAEEIVMGRH
610 620 630 640 650 660
QGNNQEFPAS QVDFVDVSPK QVVAVATACI PFLENDDSNR ALMGANMQRQ AVPLIDPKAP
670 680 690 700 710 720
YVGTGMEYQA AHDSGAAVIA QHNGKVVFSD AERVEVRRED GSLDVYHITK FRRSNSGTAY
730 740 750 760 770 780
NQRTLVKIGD IVEKGDFIAD GPSMEKGEMA LGQNPIVAYM TWEGYNFEDA VIMSERLVKE
790 800 810 820 830 840
DVYTSVHLEE FESETRDTKL GPEEITREVP NVGEEALKDL DEMGIIRIGA EVKEGDILVG
850 860 870 880 890 900
KVTPKGEKDL SAEERLLHAI FGDKSREVRD TSLRVPHGGD GIVRDVKIFT RANGDELQSG
910 920 930 940 950 960
VNMLVRVYIA QKRKIKVGDK MAGRHGNKGV VSRIVPVEDM PYLPDGTPVD IMLNPLGVPS
970 980 990 1000 1010 1020
RMNIGQVMEL HLGMAARNLG IHIATPVFDG ATSEDLWETV REAGMDSDAK TVLYDGRTGE
1030 1040 1050 1060 1070 1080
PFDNRVSVGV MYMIKLHHMV DDKLHARSVG PYSLVTQQPL GGKAQFGGQR FGEMEVWALE
1090 1100 1110 1120 1130 1140
AYGASNVLQE ILTYKSDDVN GRLKAYEAIT KGKPIPKPGV PESFRVLVKE LQSLGLDMRV
1150 1160 1170 1180
LDEDDNEVEL RDLDEGEDDD VMHVDDLEKA REKQAQETQD IAESTEDN