C0LT23
Gene name |
CERK |
Protein name |
Ceramide kinase |
Names |
OsCERK |
Species |
Oryza sativa subsp japonica (Rice) |
KEGG Pathway |
osa:4330198 |
EC number |
2.7.1.138: Phosphotransferases with an alcohol group as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for C0LT23
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-C0LT23-F1 | Predicted | AlphaFoldDB |
No variants for C0LT23
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for C0LT23 | |||||
No associated diseases with C0LT23
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.1.138 | Phosphotransferases with an alcohol group as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ceramide kinase activity | Catalysis of the reaction: ATP + ceramide = ADP + ceramide-1-phosphate. |
| dihydroceramide kinase activity | Catalysis of the reaction: ATP + a dihydroceramide = ADP + H+ + a dihydroceramide 1-phosphate. |
| lipid kinase activity | Catalysis of the phosphorylation of a simple or complex lipid. |
| metal ion binding | Binding to a metal ion. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| ceramide metabolic process | The chemical reactions and pathways involving ceramides, any N-acylated sphingoid. |
| negative regulation of programmed cell death | Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| sphingolipid metabolic process | The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEGGGEALFL | DGVGEVTVAV | GDDGLSFQPL | HQEVSSSCWS | SIIMQPKLES | KLKFSDVYAV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ELLEVGPVCE | PWNARATVQG | KINTEMNRFV | IHTVTRPRKR | PSPWVPCEYI | FGHKDQQTCK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TWVEHIKTCI | NKEQDRPKSL | MVFVHPLCGK | GRGCKNWETV | APLFERAKVK | TKVIVTQRAG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HAYDTLASLS | DKDLKKFDGV | IAVGGDGLFN | EILNGLLSTR | HTNSYPPTPE | GFGYFRNNMK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CQEHRNNDLS | NSELTGDDAN | AISGSSNTPD | DHEPLLSTTR | STGLDISSSD | SSDEPCNGDQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VPLVSFPNNW | FRLGIIPSGS | TDAIVLSTTG | ERDPVTSALL | IILGRRISLD | IAQVVRWKSS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PSAEVSPTVR | YAASFAGYGF | YGEVIRESEK | YRWMGPARYD | FSGTMVFLKH | RSYEAKVAFL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ENGNTHSLTA | SAENNANGVQ | TLQYHQNRHR | KTICRTNCLI | CKGTSTSEQN | SEDENPDSSR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TACETPKWVW | SKGRFLSVGA | AVISCRNERA | PDGLVADAHL | SDGFLHLLLI | RDCPLPFYLW |
| 550 | 560 | 570 | 580 | 590 | 600 |
| HLTQFTKKGS | DPLSFKFVEH | HKTQAFTFIS | SHDESVWNLD | GELLQACEVS | VQAFRGLVNL |
| FASGPEV |