B9L1Z5
Gene name |
mutM |
Protein name |
Formamidopyrimidine-DNA glycosylase |
Names |
Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM |
Species |
Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2) |
KEGG Pathway |
tro:trd_1895 |
EC number |
3.2.2.23: Hydrolyzing N-glycosyl compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B9L1Z5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B9L1Z5-F1 | Predicted | AlphaFoldDB |
No variants for B9L1Z5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for B9L1Z5 | |||||
No associated diseases with B9L1Z5
5 regional properties for B9L1Z5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | DNA mismatch repair protein MutS, C-terminal | 631 - 823 | IPR000432 |
| domain | DNA mismatch repair protein MutS-like, N-terminal | 9 - 120 | IPR007695 |
| domain | DNA mismatch repair protein MutS, core | 275 - 614 | IPR007696 |
| domain | DNA mismatch repair protein MutS, connector domain | 129 - 257 | IPR007860 |
| domain | DNA mismatch repair protein MutS, clamp | 451 - 541 | IPR007861 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.2.2.23 | Hydrolyzing N-glycosyl compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| class I DNA-(apurinic or apyrimidinic site) endonuclease activity | Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate. |
| damaged DNA binding | Binding to damaged DNA. |
| oxidized purine nucleobase lesion DNA N-glycosylase activity | Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site. |
| zinc ion binding | Binding to a zinc ion (Zn). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| base-excision repair | In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPELPEVETI | RRTLAPVLIG | ALVIGALRGE | HPEDILLDPW | PVFARRVRRH | RIVALERRGK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YLAARFEDGD | RLVIHLGMTG | ELRLSHPATA | PGKHCHLALV | LRSLRPLPPS | LVDQRQRFLL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RYLDIRRFGR | IALLDQAGWE | TFTARLGPEP | LDPTLDPRAL | WSRLRERRTA | IKAALLDQAL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LAGIGNIYAD | EALFQARLHP | ARRCQTLSLD | EVERLLVALR | TVLSAAIENA | GTTIRDYRDG |
| 250 | 260 | 270 | 280 | ||
| QGRAGSFQSR | LQVYGKPAGT | PCPRCGTGLA | RIRIAGRSSV | FCPRCQPLH |