B9L0Q2

PR
Gene name
hemL
Protein name
Glutamate-1-semialdehyde 2,1-aminomutase
Names
GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT
Species
Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)
KEGG Pathway
tro:trd_1123
EC number
5.4.3.8: Transferring amino groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

131-211 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B9L0Q2

Entry ID Method Resolution Chain Position Source
AF-B9L0Q2-F1 Predicted AlphaFoldDB

No variants for B9L0Q2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B9L0Q2

No associated diseases with B9L0Q2

No regional properties for B9L0Q2

Type Name Position InterPro Accession
No domain, repeats, and functional sites for B9L0Q2

Functions

Description
EC Number 5.4.3.8 Transferring amino groups
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
glutamate-1-semialdehyde 2,1-aminomutase activity Catalysis of the reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
transaminase activity Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.

1 GO annotations of biological process

Name Definition
protoporphyrinogen IX biosynthetic process The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MMMENSGSLW DAARQFFPGG VNSPVRAFRA VGEEPVVAVR GEGAYLIDAD GRRFLDYICS
70 80 90 100 110 120
WGALLAGHAH PHVVDRLSEA IQRGTSFGLL SPYEVELARA IVASVPAIEL VRFVNSGTEA
130 140 150 160 170 180
TMSAIRLARA VTGRNLVVKF AGCYHGHVDG LLVAAGSGVL TFGLPGTPGV TEGTARDTLV
190 200 210 220 230 240
LPYNDQEAVE DAFAQHGERI AAVIVEPVAG NMGVVPPAAG FLSRLRELTR QAGALLIFDE
250 260 270 280 290 300
VITGFRLGLG GAQERFGILP DLTCLGKVIG GGLPVGAYGG RRDLMEQVAP NGPVYQAGTL
310 320 330 340 350 360
AGNPLSMVAG LATLELAREP GVYGRLETLA AWLQRGLEET IQESGLPAHV QRVGSMLTLF
370 380 390 400 410 420
FSQQPVTDAQ TAERCDTARF AAFHRAMRAQ GILLPPSQFE AWFVSLAHRE EDIDRTIEAA
RKALAEVARG