B9KZP8

PR
Gene name
lysY
Protein name
Putative [LysW]-L-2-aminoadipate 6-phosphate reductase
Names
Species
Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)
KEGG Pathway
tro:trd_1518
EC number
1.2.1.103: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

151-233 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B9KZP8

Entry ID Method Resolution Chain Position Source
AF-B9KZP8-F1 Predicted AlphaFoldDB

No variants for B9KZP8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B9KZP8

No associated diseases with B9KZP8

3 regional properties for B9KZP8

Type Name Position InterPro Accession
domain Semialdehyde dehydrogenase, NAD-binding 4 - 140 IPR000534
domain Semialdehyde dehydrogenase, dimerisation domain 157 - 322 IPR012280
active_site N-acetyl-gamma-glutamyl-phosphate reductase, active site 143 - 159 IPR023013

Functions

Description
EC Number 1.2.1.103 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
N-acetyl-gamma-aminoadipyl-phosphate reductase activity Catalysis of the reaction: N(2)-acetyl-L-aminoadipate-semialdehyde + NADP+ + phosphate = N(2)-acetyl-L-gamma-aminoadipyl phosphate + NADPH.
N-acetyl-gamma-glutamyl-phosphate reductase activity Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+.
NAD binding Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

2 GO annotations of biological process

Name Definition
arginine biosynthetic process The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
lysine biosynthetic process via aminoadipic acid The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVVSVAILGG SGYTGGELLR LLLSHPEVEV KQVTSRSRAG KFVHTVHPNL RKRTALKFVP
70 80 90 100 110 120
PEALEPVDLL FACLPHGETA PIVDRLLELA PIVIDLSADF RLRDPAAYEQ WYHWTHPRPD
130 140 150 160 170 180
LLAQAVYGLP ELHREEIRNA RYIACPGCNS TTVILGLAPL FRAGLIDLDL PVTVECKVGS
190 200 210 220 230 240
SGAGGEAGPA SHHPERSGVI RPFKPGGHRH TAEVLQELTV CGRTPSLGLS VTSVEAVRGI
250 260 270 280 290 300
LATAHLFPKQ PLTDRDLWQV YRAAYGQEPF IRLVKEASGI HRYPEPKILA GSNYCDIGWE
310 320 330 340 350
LDELPGGRQR LVVMSAIDNL MKGAAGQAVQ AMNIRLGFPE TLGLEFPGLH PL