B9KAN7

PR
Gene name
thrS
Protein name
Threonine--tRNA ligase
Names
Threonyl-tRNA synthetase, ThrRS
Species
Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NBRC 107923 / NS-E)
KEGG Pathway
tna:CTN_1844
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-46 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B9KAN7

Entry ID Method Resolution Chain Position Source
AF-B9KAN7-F1 Predicted AlphaFoldDB

No variants for B9KAN7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B9KAN7

No associated diseases with B9KAN7

7 regional properties for B9KAN7

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 319 - 525 IPR002314
domain TGS 1 - 59 IPR004095
domain Anticodon-binding 538 - 627 IPR004154
domain Aminoacyl-tRNA synthetase, class II 268 - 531 IPR006195
domain Threonyl/alanyl tRNA synthetase, SAD 167 - 216 IPR012947
domain Threonine-tRNA ligase catalytic core domain 240 - 536 IPR033728
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 536 - 626 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKIKVVLPDG SEREYEKGTK PMEIAREVGI KKVIGAVVDE ELWDLKRPLE RDCRIRFVTL
70 80 90 100 110 120
EDPEAPEFYR HTMAHILAQA VMRLYGKENV KLGIGPTIEN GFYYDFDIRN GKLTEEDLPR
130 140 150 160 170 180
IEQEMKKIIK ENLPIEREEI SKDEAKEIFK DQPYKLELIE EIEGDTVTIY RQGEFVDLCR
190 200 210 220 230 240
GPHLPSTGVV KHFKLLSVSG AYWRGSEKNP MLTRVYGTAF AKKEDLENYL KFLEEAQKRD
250 260 270 280 290 300
HRKLGPQLEL FMLNTDYAPG MPFFLPRGVI VLNELMNFSR ELHRERGYQE IFTPLIMNEQ
310 320 330 340 350 360
LWRISGHWDH YAENMYFIEK GEERYAVKPM NCPGHILVYK SRAVSYRDLP LRFFEFGRVH
370 380 390 400 410 420
RYERSGVLHG LMRVRSFTQD DAHIFCTPDQ IEDEILGVLE LINTIYSQFG FTYRVELSTM
430 440 450 460 470 480
PEDHMGDEAI WEKATNALKK ALDRAGLPYR VNEGEGAFYG PKIDFHIKDS LGREWQCATI
490 500 510 520 530 540
QLDFMMPEKF NVTYIGPDNR EHTAVMIHRA IYGSLERFFG ILIEHFAGAF PTWIAPVQVA
550 560 570 580 590 600
VIPISDKHSE GAKKVATMLS REGFRVFLDD RRETLGYRIR QAQIQKIPYM VVLGDRELES
610 620 630
GKLSVRTRSG KEIKDVEMDH FIDTLKKEVR DRKLELTLEG