B9K800

PR
Gene name
mutS
Protein name
DNA mismatch repair protein MutS
Names
Species
Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NBRC 107923 / NS-E)
KEGG Pathway
tna:CTN_0907
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

746-801 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B9K800

Entry ID Method Resolution Chain Position Source
AF-B9K800-F1 Predicted AlphaFoldDB

No variants for B9K800

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B9K800

No associated diseases with B9K800

5 regional properties for B9K800

Type Name Position InterPro Accession
domain Zinc finger, DNA glycosylase/AP lyase-type 238 - 272 IPR000214
domain Zinc finger, FPG/IleRS-type 244 - 272 IPR010663
domain Formamidopyrimidine-DNA glycosylase, catalytic domain 1 - 116 IPR012319
domain DNA glycosylase/AP lyase, H2TH DNA-binding 132 - 224 IPR015886
binding_site DNA glycosylase/AP lyase, zinc finger domain, DNA-binding site 247 - 271 IPR015887

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
damaged DNA binding Binding to damaged DNA.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

1 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKMTPLMEQY LKIKEQYKDS ILLFRLGDFY EAFFEDAKTV SKVLNIVLTK RQDAPMAGIP
70 80 90 100 110 120
YHALNTYLKK LVEAGYKVAI CDQMEEPSKS KKLIRREVTR VVTPGAIVED EFLSETNNYM
130 140 150 160 170 180
VVLVREKEKY CAVFCDVSTG EVLIHESIDE QEVLDLMKAY SVSEIVCPEG LESEVREKLP
190 200 210 220 230 240
GVYIEVIDEW YFSEPEEEVK RIYGIEDIHH FELSSLAMKS LSALIKYIKY TMISEKLNLK
250 260 270 280 290 300
PPVTISRKNF MILDSATVEN LSLIPGEKGK NLFDVLNHTE TPMGARLLKK WILHPLTDRQ
310 320 330 340 350 360
QIEDRLNAVE KLKEDRLKLE QIRNLLSRVR DVERIVSRVE YNRAIPRDLV ALRETLSVVP
370 380 390 400 410 420
ELNEELSNFD FFEKLNFPDS LFDLLCKAIE DDPAGSPGEG KVIKRGFSPE LDEYRDLLEH
430 440 450 460 470 480
SEEKLKEFEE REREKTGIQK LKVGYNQVFG YYIEVTKANL DKVPEDYERK QTLVNSERFT
490 500 510 520 530 540
TPELKEFETK IMAAKERIEE LEKELFRNVC EEVKKHKETL LEISEELARI DVLATLAYDA
550 560 570 580 590 600
ILYNYTRPTF SEDRMEIIGG RHPVVERFTR DFVENDLYMD DEKRFTVITG PNMSGKSTFI
610 620 630 640 650 660
RQVGLISLMA QIGSFVPAKK AVLPVFDRIF TRMGARDDLA GGRSTFLVEM NEMALILLKA
670 680 690 700 710 720
TKKSLVLLDE VGRGTGTQDG ISIAWAISEE LISRGCKVLF ATHFIELTNL ENSFPQVQNK
730 740 750 760 770 780
TILVKEEGSN VVFTHRVVDG VADRSYGADR SYGIEVARIA GIPENVIRRA FEIMEKGFKT
790 800
KSQRKNGKVK KFSQQIPLFP A