B9JWL2

PR
Gene name
dnaE2
Protein name
Error-prone DNA polymerase
Names
Species
Agrobacterium vitis (strain S4 / ATCC BAA-846) (Rhizobium vitis (strain S4))
KEGG Pathway
avi:Avi_2294
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

846-915 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B9JWL2

Entry ID Method Resolution Chain Position Source
AF-B9JWL2-F1 Predicted AlphaFoldDB

No variants for B9JWL2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B9JWL2

No associated diseases with B9JWL2

5 regional properties for B9JWL2

Type Name Position InterPro Accession
domain Polymerase/histidinol phosphatase, N-terminal 4 - 71 IPR003141
domain PHP domain 5 - 105 IPR004013
domain Bacterial DNA polymerase III, alpha subunit, NTPase domain 272 - 525 IPR011708
domain DNA polymerase, helix-hairpin-helix motif 767 - 858 IPR029460
domain DNA polymerase III alpha subunit finger domain 528 - 694 IPR040982

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.

2 GO annotations of biological process

Name Definition
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRYAELQVTT HFSFLRGASS AIELFETAKS LGIDAIGVVD RNSLAGIVRA LEASRATGVR
70 80 90 100 110 120
LVVGCRLDLQ DGMSILVYPT DRTAYSRLAR LITLGKGRGG KDNCILMLDD IAQYGEGLLG
130 140 150 160 170 180
ILVPDLADDT CAVQLRKMAE VFGDLAYLSL CLRRRPNDQL RLHELSNMAT RFKVKTVVTN
190 200 210 220 230 240
DVLFHEPGRR QLQDIVTCIR NNTTIDTVGF ERERHADRYL KPPEEMERLF PRYRQALRRT
250 260 270 280 290 300
MEIVDRCKFS LEELTYQYPE EAIVPRKTAQ ESLEHYVWQC VPDRYPQGLP PKTLQIIRHE
310 320 330 340 350 360
LDLIHKMKYA PYFLTVFSIV RFARAKGILC QGRGSAANSA VCYILGVTSI DPETNNLLFE
370 380 390 400 410 420
RFVSQERDEP PDIDVDFEHE RREEVIQWIY KTYGKEKAAL CATVNRYRAK GAIRDVGKAL
430 440 450 460 470 480
GLPEDLIKAL SSGMWSWSQE TSDRNVRELN LNPDDRRLTL TLQLAQQLMG APRHLGQHPG
490 500 510 520 530 540
GFVLTHDRLD DLVPIEPSTM EDRQIIEWDK DDVEALKFMK VDVLALGMLT CMSKVFALIR
550 560 570 580 590 600
EHKGDDLDLA KIRQEDKATY EMICKADTLG TFQIESRAQM AMLPRLKPKT FYDLVVQVAI
610 620 630 640 650 660
VRPGPIQGDM VHPYLRRREK KEDVDYPTPE LEAVLGKTLG VPLFQESAMR VAMVCAGFTG
670 680 690 700 710 720
GEADQLRKSM ATFKFTGGVS RFKEKLVSGM VKNGYTPEFA EKTFSRLEGF GSYGFPESHA
730 740 750 760 770 780
ASFALIAYAS NYVKCHFPDV FCAALLNSQP MGFYAPAQIV GDARAHGVEV RPVCVNRSRW
790 800 810 820 830 840
DCTLERIGTT QQHAVRLGMR MVKGLVVADV ARIVAARMNG PFDSVDDMWR RSGVPAASLV
850 860 870 880 890 900
ELAHADAFQP SLKLARRDVL WAIKALRDEP LPLFAAAAER EMKTIAEQNE PEVELRQMTK
910 920 930 940 950 960
GHNVVEDYGH IGLTLRDHPI AFLRTDLAKR NIVTCEEAMT ARDGRWVITA GLVLVRQKPG
970 980 990 1000 1010 1020
SAKGVMFITI EDETGPANIV VWPKLFEKRR RIVLGSSMMA IHGRIQREGE VVHLIAQQLF
1030 1040 1050 1060 1070 1080
DLTSDLSGLA DRDMEFKLPT GRGDEFAHGS PGGGDSRDRS PPKPRDIVVP LCRARHKGID
1090
PEPETMPSAF PKPRDFR