B9JWF4

PR
Gene name
thrS
Protein name
Threonine--tRNA ligase
Names
Threonyl-tRNA synthetase, ThrRS
Species
Agrobacterium vitis (strain S4 / ATCC BAA-846) (Rhizobium vitis (strain S4))
KEGG Pathway
avi:Avi_2211
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

599-666 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B9JWF4

Entry ID Method Resolution Chain Position Source
AF-B9JWF4-F1 Predicted AlphaFoldDB

No variants for B9JWF4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B9JWF4

No associated diseases with B9JWF4

7 regional properties for B9JWF4

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 337 - 547 IPR002314
domain TGS 1 - 64 IPR004095
domain Anticodon-binding 560 - 647 IPR004154
domain Aminoacyl-tRNA synthetase, class II 245 - 553 IPR006195
domain Threonyl/alanyl tRNA synthetase, SAD 171 - 221 IPR012947
domain Threonine-tRNA ligase catalytic core domain 244 - 558 IPR033728
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 558 - 648 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDTVSLTFP DGSVRSFAAG ATGRDVAESI SKSLAKKAVA IALDGVVRDL ADPVVDGKIE
70 80 90 100 110 120
IVTRADPRAL ELIRHDTAHV LAEAVQEMWP GTQVTIGPVI ENGFYYDFAK NEPFTPEDLP
130 140 150 160 170 180
KIEKKMKEII QRNQPFRKEV WSREKAREVF AAKGESYKVE LIDAIPEDQD IKIYYQGDWF
190 200 210 220 230 240
DPCRGPHMAS TGQIGTAFKL MKVAGAYWRG DSNNPMLTRI YGTAFAEQEQ LDNYLHILAE
250 260 270 280 290 300
AEKRDHRKLG REMDLFHFQE EGPGVVFWHG KGWKMFQSLT AYMRRRLANT YQEVNAPQVL
310 320 330 340 350 360
DKSLWETSGH WGWYQENMFA VKSAHAFTNP NDPEADQRVF ALKPMNCPGH VQIFKHGLKS
370 380 390 400 410 420
YRELPVRLAE FGLVHRYEAS GALHGLMRVR GFTQDDAHVF CTEEQMAAEC LRINDLILSV
430 440 450 460 470 480
YEDFGFKEVV VKLSTRPEKR VGSDELWDRA ESVMTEVLKA IEEQSGGRIK TGILPGEGAF
490 500 510 520 530 540
YGPKFEYTLK DAIGREWQCG TTQVDFNLPE RFGAFYIDQH SEKTQPVMIH RAICGSMERF
550 560 570 580 590 600
LGILIENFAG HMPLWFAPLQ VVVATITSEA DDYGRDVAEQ LRDAGLEVET DFRNEKINYK
610 620 630 640 650 660
VREHSVGKVP VIMVCGKREA EERTVNIRRL GSQDQVSMTL DEAIASLVDE ATPPDVKRKR
AARKPA