B9EJR8
Gene name |
Dnaaf5 |
Protein name |
Dynein axonemal assembly factor 5 |
Names |
HEAT repeat-containing protein 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:433956 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B9EJR8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B9EJR8-F1 | Predicted | AlphaFoldDB |
33 variants for B9EJR8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs242701426 | 13 | P>A | No | EVA | |
| rs256490713 | 53 | V>A | No | EVA | |
| rs3413000469 | 117 | P>T | No | EVA | |
| rs248112350 | 136 | C>S | No | EVA | |
| rs217516667 | 142 | A>T | No | EVA | |
| rs3396210336 | 294 | D>G | No | EVA | |
| rs3388792163 | 300 | R>W | No | EVA | |
| rs3388803207 | 340 | E>D | No | EVA | |
| rs3388795354 | 361 | A>D | No | EVA | |
| rs3388795354 | 361 | A>V | No | EVA | |
| rs216306273 | 399 | V>I | No | EVA | |
| rs264358543 | 416 | G>S | No | EVA | |
| rs3388805352 | 417 | S>C | No | EVA | |
| rs3388774275 | 434 | F>L | No | EVA | |
| rs3388805667 | 447 | S>Y | No | EVA | |
| rs3388795333 | 482 | I>F | No | EVA | |
| rs37590547 | 517 | F>L | No | EVA | |
| rs3388809021 | 564 | L>R | No | EVA | |
| rs3395912050 | 581 | Q>H | No | EVA | |
| rs3396279556 | 582 | L>F | No | EVA | |
| rs3396274061 | 582 | L>W | No | EVA | |
| rs3388800518 | 616 | D>Y | No | EVA | |
| rs37296281 | 629 | M>T | No | EVA | |
| rs3388805376 | 638 | V>D | No | EVA | |
| rs3388803121 | 645 | R>H | No | EVA | |
| rs3388805373 | 647 | Y>F | No | EVA | |
| rs3388774280 | 681 | A>T | No | EVA | |
| rs216648571 | 714 | T>I | No | EVA | |
| rs3396134499 | 765 | L>F | No | EVA | |
| rs3413000333 | 765 | L>M | No | EVA | |
| rs3388774235 | 814 | G>C | No | EVA | |
| rs3388785704 | 821 | V>M | No | EVA | |
| rs3388774219 | 844 | Q>* | No | EVA |
No associated diseases with B9EJR8
1 regional properties for B9EJR8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | TOG domain | 118 - 335 | IPR034085 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| dynein axonemal particle | An aggregation of axonemal dyneins, their specific assembly factors, and broadly-acting chaperones that is located in the cytoplasm. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| dynein intermediate chain binding | Binding to an intermediate chain of the dynein complex. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cilium movement | The directed, self-propelled movement of a cilium. |
| inner dynein arm assembly | The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. |
| outer dynein arm assembly | The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAPAEAEVA | AAPGLTEAAE | AAELTRALSR | LLPGLETESK | LGRRRALEAL | EQVLEEAVRP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GADSAAFQGP | WARLLLPRLL | RLLSDPAEGC | RALAAHLLDL | GLRRAARPRD | ALPRLLPALS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ARLARPELAR | PPPEPCEELR | LALVQLLHLA | VDLGGAALAP | HLDDAVRALR | AALLDPFAAV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RREGCECAAA | LARATPEHFH | MQSESLIGPL | MQTISHQHWK | VRVAVIEATG | TVIQFGSGNS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VDDVLSHFAQ | RLFDDVPQVR | QAVTSVVGGW | LLNLRDRYSF | LHKLTPLLLS | SFSDEMPEIR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QTATSLWEKV | GLQWQQENEA | DLKDKLDFAS | PPPPNYPEHE | SRPGLGCREL | VFRNLSKVLP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AICHDITDWV | VGTRVKAAQL | LPVLLLHAED | HITQHLEIVL | RTLHQACTDE | EKAVVGSCIR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AAELIGTFVS | PEVFLKLILA | MLKKAPSASG | LLILASVIRG | CPRNALQPHV | TVIATELAQE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| HICQGSENNL | YLEHLLLCVQ | ALLSVCQEDC | RAASLQFLEV | LVTIMAVSDA | VGLEKKAQKT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| MDTLAEVEDI | PSSQDLYRKH | VGALLERLTA | SHGEWAVHSV | QLLKFTVLLT | QAGPAVGEAL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QHVIPTLRAC | LQPSTDPHMR | LKLFSILSMM | LLRPKDTVDS | QGQFRGYLDM | VINDILAPNL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QWHAGRTAAA | IRTAAISCLW | ALISSDILSA | KQVQEAQETL | MPQVLATLED | DSQTTRLMSC |
| 730 | 740 | 750 | 760 | 770 | 780 |
| RIINMFLKNS | GDTMEPEKFL | KVYPELLKRL | DDVSNDVRMA | AASALLTWLK | CIESLDGKSA |
| 790 | 800 | 810 | 820 | 830 | 840 |
| YQSSVQFLYR | ELLVHLDDPE | SAIQDTVLEV | LKEGSVLFPD | VLVRETEAVV | HKHRSATYCE |
| 850 | |||||
| QLLQHMQTMA | AAR |