B9EBI5

PR
Gene name
mutL
Protein name
DNA mismatch repair protein MutL
Names
Species
Macrococcus caseolyticus (strain JCSC5402)
KEGG Pathway
mcl:MCCL_0889
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

49-133 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B9EBI5

Entry ID Method Resolution Chain Position Source
AF-B9EBI5-F1 Predicted AlphaFoldDB

No variants for B9EBI5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B9EBI5

No associated diseases with B9EBI5

6 regional properties for B9EBI5

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 6 - 245 IPR003439
domain AAA+ ATPase domain 35 - 222 IPR003593
domain ABC3 transporter permease protein domain 538 - 650 IPR003838
conserved_site ABC transporter-like, conserved site 147 - 161 IPR017871
domain MacB, ATP-binding domain 6 - 223 IPR017911
domain MacB-like periplasmic core domain 284 - 501 IPR025857

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mismatch repair complex Any complex formed of proteins that act in mismatch repair.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

1 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGIIKTLDST ISNKIAAGEV IERPQSVVKE LVENAIDAKS TSITIEVEEA GLSKIKVTDN
70 80 90 100 110 120
GSGILEEDLE LMFRRHATSK IENEHDLFHI RSLGFRGEAL ASIASVSKVR VTTCHDGSIG
130 140 150 160 170 180
RQIDVIDGET VNRTLAQARQ GTEITVESLF YNTPARLKYV KSLHTELGKI TDIINRFVIS
190 200 210 220 230 240
FPYIKFTLVA DGRVLIASNG NGKMQEAMAV VYGMKIAQDL VEVNGRTGDY EVHGFIAKPE
250 260 270 280 290 300
HTRSNRHYMS LFINGRYIKN FMLTKAILSG YHTLLPVGRY PILAINIVMD PALVDVNVHP
310 320 330 340 350 360
TKQEVRLSKE SQLMELIERL IKEKIWKQNL IPKVEKKKVL ETFQQQKFEY DLLREHRDKT
370 380 390 400 410 420
KQSDYSEQTA VNQIDEKFKE QHKTAQLDKQ RVPDGESTQK TTGFISDSAA ELDTTSEILP
430 440 450 460 470 480
EKNESSDVIE NISTDTSREK RKIPYMEIVG QVHGTYIIAQ NEDGMFMIDQ HAAQERIKYE
490 500 510 520 530 540
YFKKQIGDVG LEMQSLLIPI TVTLSKDEAI NLNKINILLK DIGIHLEHFG GNDYIINDIP
550 560 570 580 590 600
VWFPDNYEET VQELIDYALQ HRQIDLNKFR EETAIMMSCK KSIKANHYLR ITDMNYLLEE
610 620 630
LAHTVEPYTC PHGRPIIIQF TTYELEKLFK RVM