B9DND4

PR
Gene name
valS
Protein name
Valine--tRNA ligase
Names
Valyl-tRNA synthetase, ValRS
Species
Staphylococcus carnosus (strain TM300)
KEGG Pathway
sca:SCA_1269
EC number
6.1.1.9: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-62 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B9DND4

Entry ID Method Resolution Chain Position Source
AF-B9DND4-F1 Predicted AlphaFoldDB

No variants for B9DND4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B9DND4

No associated diseases with B9DND4

5 regional properties for B9DND4

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 44 - 55 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 16 - 559 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 604 - 752 IPR013155
domain Valyl-tRNA synthetase, tRNA-binding arm 810 - 875 IPR019499
domain Valyl tRNA synthetase, anticodon-binding domain 559 - 695 IPR033705

Functions

Description
EC Number 6.1.1.9 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
valine-tRNA ligase activity Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEMKPKYNPT EVEAGRYQEW VEKGYFRPSG DKSKETYTIV IPPPNVTGKL HLGHAWDTTL
70 80 90 100 110 120
QDILTRMKRM QGYDTLYLPG MDHAGIATQA KVEAKLNEQG ISRHDIGREK FLEEVWSWKD
130 140 150 160 170 180
EYASFIRQQW AKLGLGLDYD RERFTLDEGL SKAVRKVFVD MYNKGLIYRG ERIINWDPEA
190 200 210 220 230 240
RTALSDIEVV HEDVEGKFYH FKYPYADGEG YIEIATTRPE TMLGDTAIVV NPDDERYKDV
250 260 270 280 290 300
IGKKVILPIV NRELPILADE YVDVEFGSGA MKVTPAHDPN DFEIGQRHNL ESIIVMDEEG
310 320 330 340 350 360
KMNDKAGKYE GMDRFECRAQ LVEDLKEQDL VIKIEDHVHA VGHSERTGAV VEPYLSTQWF
370 380 390 400 410 420
VNMEPLAKQA LDNQKTDNRI NFVPERFEHT FNQWMENIRD WTISRQLWWG HQIPAWYHKE
430 440 450 460 470 480
TGEIYVGETE PEDAENWVQD EDVLDTWFSS GLWPFSTLGW PDVESEDYQR YYPTNALVTG
490 500 510 520 530 540
YDIIFFWVAR MIFQGLEFTG ERPFDDVLLH GLVRAEDGRK MSKSLGNGVD PMDVINEYGA
550 560 570 580 590 600
DSLRYFLATG SSPGHDLRYS TEKVESVWNF INKIWNAARF SIMNIGEEFK FEDIDLSKNL
610 620 630 640 650 660
SLADKWILTR LNETIKTVTD LSDRYEFGEV GRALYNFIWD EFCDWYIEMS KIPMNGEDEA
670 680 690 700 710 720
QKQVTRSVLS YVLERTMRML HPYMPFVTEE IWQNLPHVGE TIVTSAWPEV EEAYMFEESK
730 740 750 760 770 780
QAMQYVVEII KAVRQARSEV NTPLSKAIPI YIKTKDAEIK QMLDENQHYL ERFGHPSELV
790 800 810 820 830 840
ISTDIETPDK AMTSVVGAGE VILPLEGLID MDKEIARLEK EIDKWQSELD RVDKKLSNEN
850 860 870
FVNKAPEKII NEEKAKKHDY QEKFDSVKAR IEQLKA