B8MS24

PR
Gene name
guf1 (TSTA_002680)
Protein name
Translation factor guf1, mitochondrial
Names
Elongation factor 4 homolog, EF-4, GTPase guf1, Ribosomal back-translocase
Species
Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

14-87 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B8MS24

Entry ID Method Resolution Chain Position Source
AF-B8MS24-F1 Predicted AlphaFoldDB

No variants for B8MS24

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B8MS24

No associated diseases with B8MS24

6 regional properties for B8MS24

Type Name Position InterPro Accession
domain DNA gyrase B subunit, C-terminal 565 - 626 IPR002288
domain Histidine kinase/HSP90-like ATPase 33 - 177 IPR003594
domain TOPRIM domain 420 - 534 IPR006171
domain DNA topoisomerase, type IIA, subunit B, domain 2 222 - 392 IPR013506
conserved_site DNA topoisomerase, type IIA, conserved site 424 - 432 IPR018522
domain DNA gyrase subunit B, TOPRIM domain 420 - 533 IPR034160

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
ribosome binding Binding to a ribosome.

2 GO annotations of biological process

Name Definition
positive regulation of translation Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
translation The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRGCLQVLRW LSTSPARRPV SSGLRLRSYE IVSPSILRPF TSTVRRQAQA SRNVSDLEKR
70 80 90 100 110 120
IAEIPIERFR NFCIVAHVDH GKSTLSDRLL ELTGVIEPGS NKQVLDKLDV ERERGITVKA
130 140 150 160 170 180
QTCTMLYNHN GEDYLLHLID TPGHVDFRAE VSRSYASCGG ALLLVDASQG VQAQTVANFY
190 200 210 220 230 240
LAFAQGLELV PVLNKVDLPS ADPERALEQM RSSFELDTDN AIKVSAKTGL NVEQLLPTVI
250 260 270 280 290 300
ERIPAPVGDH TNALRMLLVD SWYSTYKGVI LLVRVFDGEI RAGDQVVSFA TGLKYYVGEV
310 320 330 340 350 360
GIMYPDQTPQ SVLRAGQVGY IYFNPGMKRS KEAKIGDTFT KVGYEKKVEP LPGFEEPKSM
370 380 390 400 410 420
VFVAAYPSDA DHFEHLEDSV NQLILNDRSI TVQKESSEAL GAGFRLGFLG TLHCSVFEDR
430 440 450 460 470 480
LRHEHGASIL ITPPTVPVKV IYKDGKEVTV TNPAHFPDED EIRAKVAELR EPYVMATLTF
490 500 510 520 530 540
PDEYLGKVIE LCEANRGIQH TLEYFTSSQV ILKYELPLGQ LVEDFFGKLK GSTKGYATLD
550 560 570 580 590 600
YEEAGWKASN IVKLQLLVNK KPVDAVARIV HYSQVERLGK QWVTKFKEHV DRQMFEIIIQ
610 620 630 640 650 660
AAVGRKVVAR ETIKPYRKDV LAKLHASDVS RRRKLLEKQK EGRKRLNAIG NVVIDHSAFQ
AFLSK