B8J008

PR
Gene name
mutS
Protein name
DNA mismatch repair protein MutS
Names
Species
Desulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949 / MB)
KEGG Pathway
dds:Ddes_1181
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

801-927 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B8J008

Entry ID Method Resolution Chain Position Source
AF-B8J008-F1 Predicted AlphaFoldDB

No variants for B8J008

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B8J008

No associated diseases with B8J008

5 regional properties for B8J008

Type Name Position InterPro Accession
domain DNA mismatch repair protein MutS, C-terminal 639 - 831 IPR000432
domain DNA mismatch repair protein MutS-like, N-terminal 9 - 120 IPR007695
domain DNA mismatch repair protein MutS, core 274 - 622 IPR007696
domain DNA mismatch repair protein MutS, connector domain 129 - 256 IPR007860
domain DNA mismatch repair protein MutS, clamp 458 - 549 IPR007861

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
damaged DNA binding Binding to damaged DNA.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

1 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSEPTFKMTP MFEHYMSIKA DYPDALLFYR MGDFYELFFD DAELAARELQ ITLTSRSRDP
70 80 90 100 110 120
NNPIPMCGVP WHAVDTYVAQ LVDKGYHIAI CDQVEDPKTS KGLVKRAVTS VKTPGTVLDD
130 140 150 160 170 180
ANLSTKSHNY LGALCPGSDA EKGGFAWLDV STGQWSGVDF RRQTELWQWV LKMAPRELLV
190 200 210 220 230 240
PEGFQPPART LLEGIRLVRL PLSRFDLKRS TERVLAAQGV REAAALGLEG REEIMRACGA
250 260 270 280 290 300
LLAYLAQTQM RSPEHLQPFL RLDLSRRLII DEVTERNLEI FTRLNGRKGK GTLRHVLDET
310 320 330 340 350 360
MTPMGGRLLE DMLRHPWREI SPIVRIQDAV EWFYVDDGRR TALREALNGV YDMERLSTRI
370 380 390 400 410 420
SLNQGSPRDF IALRNSLAAL PQVFTALIEP TTSLLLRPDQ EKDASENTSQ ENGLTQPRAL
430 440 450 460 470 480
TELLKTWDAM EDCAQLLQSA LVDNPPPVIT DGGLFKSGYN AELDRLLDLA EHGEQKLQAM
490 500 510 520 530 540
LAEEQSTTGI AKLKLGYNRV FGYYFEVSRA AHSGTVPYHF IRRQSLANAE RFTTEALKNL
550 560 570 580 590 600
EEELLSASDK RKALEYTLFQ DLRQHMADQR ERIAHMAQLI AHLDYWQSLA QVGRLNNWCR
610 620 630 640 650 660
PGLETDGNLT IREGRHPVVE AMIGRANFVP NDFRLDEKRR LCLLTGPNMA GKSTVLRQVA
670 680 690 700 710 720
IICLLAQMGS MVPATSARLG LVDRLFSRVG ASDNLAQGQS TFMVEMMETA RILRQATKRS
730 740 750 760 770 780
LIILDEIGRG TSTYDGVALA WAMVEDLSRR AQGELRTLFA THYHELTALE GRVDGVFTMN
790 800 810 820 830 840
IAISEYSGDI LFLHKLVPGP ADRSYGVEVA RLAGVPGPVV QRARAILANL ERGRDVARKA
850 860 870 880 890 900
VVSAVCLPGI DLPETGPEED MPVLQAAPPR SEHPVIELLR QIEPEELSPL DALKTLMEWK
910 920
KLWSAQPGSA EQGESPDKHD EGKNSRG