B8I2Y3

PR
Gene name
addB
Protein name
ATP-dependent helicase/deoxyribonuclease subunit B
Names
ATP-dependent helicase/nuclease AddB
Species
Ruminiclostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10) (Clostridium cellulolyticum)
KEGG Pathway
cce:Ccel_1775
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

579-729 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B8I2Y3

Entry ID Method Resolution Chain Position Source
AF-B8I2Y3-F1 Predicted AlphaFoldDB

No variants for B8I2Y3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B8I2Y3

No associated diseases with B8I2Y3

2 regional properties for B8I2Y3

Type Name Position InterPro Accession
domain UvrD-like DNA helicase, C-terminal 305 - 657 IPR014017
domain PD-(D/E)XK endonuclease-like domain, AddAB-type 777 - 1116 IPR038726

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

7 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
5'-3' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.
double-stranded DNA binding Binding to double-stranded DNA.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
double-strand break repair via homologous recombination The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGLQFIYGRA GSGKSFHCLN SIKTKQNKDS NKKLVLIVPE QYTLQAERDL IKVLGTGGIL
70 80 90 100 110 120
KTEVLSFRRM AYRVLNEVGG ITYPHIHPSG KNMIIYRILE RLKDQFTIFH KSANCKGFVN
130 140 150 160 170 180
TLSTLITELK RYNVRAESFD EVLQGLADDN YLSHKLKEIK LIYSEFDSML VDRYRDTDDE
190 200 210 220 230 240
LTLLSSKLEG TEIYAKSEIW IDGFAGFTPQ EVEVISKLIQ QAENVHITMC TDILFDDVQA
250 260 270 280 290 300
DLTDVFAAVK KSCKKFVSIA ESYGVKILPP VCLNTPNLPR FKDSRELQSL ETNYCSYSYR
310 320 330 340 350 360
AYQLPTQDIE LFESVNIYTE IEECARDIIK QCRDNGMQFK DITVATRNLT GYENLIGVIF
370 380 390 400 410 420
EQYNIPCFID SKTEITNHPL VRMVLSMLEI FTENWSYESV FRYLKSGLTG IDNTKIDILE
430 440 450 460 470 480
NYVLACGIRG SRWTQEADWN TSIEFRPDDG QKPENDEMLL NINKTRNEIR EPLIRFRNRT
490 500 510 520 530 540
KGRRTAGDFC AGIYEYLVEI GVEQRIRNYI EKFTQSGQLR LAGEYQQVWN ILMDVFDQAV
550 560 570 580 590 600
EVMADETFGL EKFANVFKIG LAEYKISSIP ASLDQVLVGS IEHIRSHEIK ALYILGTNDG
610 620 630 640 650 660
VFPSAGMSEG VLSDADREVL DKRGIELASD TKTRAFDEQY LIYRTLTTPK NYLRLSWPIA
670 680 690 700 710 720
DHEGRTMRPS TIISRMRKIF PKVTEKSNIV KPSADKQHID LIASPIPAFN QLVCALRQKN
730 740 750 760 770 780
EGIEQGEIWR EIFAWFSGQD EWKQKCDAMI NALKYRNIAA PVDKSKIREL YGKSPYFTVS
790 800 810 820 830 840
RLEKYTSCPF AFYVQYGLGA RERKIYRMSP PDVGTFMHAV IERFSKMVDE NNYSWREFDR
850 860 870 880 890 900
QWCSEQVSKI VDELLDSMKN TILGGSKRFK ALAVRLKRVV TRAVWLITEH IRRSSFEPVG
910 920 930 940 950 960
YEVDFGDGGA YPPMVIELDS GEKIRLVGRI DRIDALRAEN GTYLRIVDYK SGEKDFKLSD
970 980 990 1000 1010 1020
VYYGLQMQLI TYLDALWEYS DKSNGEKIIP GGILYFRIDD PMIRCTDNST PEEIETAIMK
1030 1040 1050 1060 1070 1080
KLKMKGLLLA DVQLIKYMDN TIEGNSIIIP ARINKGDVLG KSSAATIEQF TVLRSYVKQL
1090 1100 1110 1120 1130 1140
LKDMCSELMK GNVPISPYKK KKLTSCSYCN YSSVCQFDQS QKENSFRMLH DREDNDIWKL
MNEIDVKDN