B8I1A0

PR
Gene name
argH
Protein name
Argininosuccinate lyase
Names
ASAL, Arginosuccinase
Species
Ruminiclostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10) (Clostridium cellulolyticum)
KEGG Pathway
cce:Ccel_1344
EC number
4.3.2.1: Lyases acting on amides, amidines, etc
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

403-459 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B8I1A0

Entry ID Method Resolution Chain Position Source
AF-B8I1A0-F1 Predicted AlphaFoldDB

No variants for B8I1A0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B8I1A0

No associated diseases with B8I1A0

3 regional properties for B8I1A0

Type Name Position InterPro Accession
conserved_site Fumarate lyase, conserved site 275 - 284 IPR020557
domain Fumarate lyase, N-terminal 6 - 300 IPR022761
domain Argininosuccinate lyase, C-terminal 363 - 430 IPR029419

Functions

Description
EC Number 4.3.2.1 Lyases acting on amides, amidines, etc
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
argininosuccinate lyase activity Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine.

1 GO annotations of biological process

Name Definition
arginine biosynthetic process via ornithine The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKLWGGRFAK GTDKLVDDFN SSIRFDSRMY RHDILGSIAH ANMLGKCGII SADESSLIQS
70 80 90 100 110 120
SLKNILNDIE AGKIDFEIDA EDIHMNVEKI LISRIGDTGK KLHTGRSRND QVALDIRMYL
130 140 150 160 170 180
RDEIISIKEM VAVLLNTLVK MSESNLDTIM PGYTHLQRAQ PITLAHHMMA YFEMFKRDYQ
190 200 210 220 230 240
RLCDCYSRMN ILPLGSGALA GTTYPLDRYM VAQELGFDDV TSNSLDGVSD RDFAIELASC
250 260 270 280 290 300
LSILMMHLSR LSEEVILWSS HEFSFVELDD AYSTGSSIMP QKKNPDVAEL ARGKTGRVYG
310 320 330 340 350 360
SLMTLLTVMK SLPLAYNKDM QEDKEAIFDA VDTVKMCLPV FSNMIGTMKV RKENMYKAAQ
370 380 390 400 410 420
GGFTNATDIA DYLVKKGIPF RTAHEIIGKM VLYCIENSKA IDDMTMEEFK SFSDKIQEDV
430 440 450
YTEISLEKCV SGRKLVGGPA RETEEKAIEN AKSFLSSLD