B8HW33
Gene name |
pyrD |
Protein name |
Dihydroorotate dehydrogenase (quinone) |
Names |
DHOdehase, DHOD, DHODase, Dihydroorotate oxidase |
Species |
Cyanothece sp (strain PCC 7425 / ATCC 29141) |
KEGG Pathway |
cyn:Cyan7425_0825 |
EC number |
1.3.5.2: With a quinone or related compound as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B8HW33
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B8HW33-F1 | Predicted | AlphaFoldDB |
No variants for B8HW33
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for B8HW33 | |||||
No associated diseases with B8HW33
3 regional properties for B8HW33
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Dihydroorotate dehydrogenase, conserved site | 96 - 115 | IPR001295-1 |
| conserved_site | Dihydroorotate dehydrogenase, conserved site | 312 - 332 | IPR001295-2 |
| domain | Dihydroorotate dehydrogenase domain | 61 - 360 | IPR005720 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.3.5.2 | With a quinone or related compound as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| dihydroorotate dehydrogenase activity | Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| 'de novo' pyrimidine nucleobase biosynthetic process | The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. |
| 'de novo' UMP biosynthetic process | The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD(+) or oxygen. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNVYQSLLQP | FVFQTLRADP | ETVKLQLLRL | GESIERHSDR | PPARWIKQQL | AQTFSLPTPE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LSQQLWGLTF | PNPIGLAAGL | DKDGVAAGLW | GSFGFGFAEV | GTVTYHPQPG | NPRPRLFRLP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ADRAGINRMG | FNNRGAAALA | QTLEQAQKRS | ARTIPLGINL | GKSKVTPLEE | AVEDYLGSFR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LLQAWGDYFV | INVSSPNTPG | LRSLQTAANL | EPILSALQNE | NQARRPLLLK | ISPDLAWEDL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ATIIDLVKTY | QWAGLIATNT | TIARPELQTK | VIPQTGKSPQ | EEAGGLSGAP | LKQRSTEVIR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FIHQQTGGQL | PIIGVGGVFT | AADAWEKIMA | GATLIQVYTG | WIYEGPGMVK | QLLTGLQTEL |
| 370 | |||||
| QQRGLDCLAA | LDRQP |