B8HD15
Gene name |
rpoC |
Protein name |
DNA-directed RNA polymerase subunit beta' |
Names |
RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta' |
Species |
Pseudarthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794 / A6) (Arthrobacter chlorophenolicus) |
KEGG Pathway |
ach:Achl_2696 |
EC number |
2.7.7.6: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B8HD15
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B8HD15-F1 | Predicted | AlphaFoldDB |
No variants for B8HD15
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for B8HD15 | |||||
No associated diseases with B8HD15
7 regional properties for B8HD15
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | RNA polymerase, alpha subunit | 419 - 462 | IPR000722-1 |
| domain | RNA polymerase, alpha subunit | 470 - 560 | IPR000722-2 |
| domain | RNA polymerase, N-terminal | 310 - 589 | IPR006592 |
| domain | RNA polymerase Rpb1, domain 3 | 564 - 722 | IPR007066 |
| domain | RNA polymerase Rpb1, domain 1 | 9 - 417 | IPR007080 |
| domain | RNA polymerase Rpb1, domain 5 | 829 - 1195 | IPR007081 |
| domain | RNA polymerase Rpb1, domain 4 | 758 - 817 | IPR007083 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.6 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| DNA-directed RNA polymerase complex | A protein complex that possesses DNA-directed RNA polymerase activity. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-directed 5'-3' RNA polymerase activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| zinc ion binding | Binding to a zinc ion (Zn). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA-templated transcription | The synthesis of an RNA transcript from a DNA template. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSESSFGLM | QIGLATAEDI | RGWSYGEVKK | PETINYRTLK | PEKDGLFCEK | IFGPSRDWEC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YCGKYKRVRF | KGIICERCGV | EVTRAKVRRE | RMGHIELAAP | VTHIWYFKGV | PSRLGYLLDL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| APKDLEKVIY | FAAYMITSVD | EAARHEELPN | LQVEHDIEKK | QLIDNRDGDI | AAIARDLEGE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IARLEGEGAK | AADKKKARDS | ADRQMANVRK | RADADIERLE | QVWDRFKNLK | VADLEGDEGL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YRELRDRYGM | YFEGSMGAEA | IKKRLEGFDM | QAESDLLRDI | IANGKGQRKT | RALKRLKVVN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AFLTTNNSPL | GMVLDAVPVI | PPELRPMVQL | DGGRFATSDL | NDLYRRVINR | NNRLKRLLDL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GAPEIIVNNE | KRMLQEAVDS | LFDNGRRGRP | VTGPGNRPLK | SLSDMLKGKQ | GRFRQNLLGK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RVDYSGRSVI | VVGPQLKLHQ | CGLPKQMALE | LFKPFVMKRL | VDLNHAQNIK | SAKRMVERYR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PQVWDVLEEI | ITEHPVLLNR | APTLHRLGIQ | AFEPQLVEGK | AIQLHPLVCG | AFNADFDGDQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| MAVHLPLSPE | AQAEARILML | SSNNILKPSD | GRPVTLPSQD | MIIGLYHLTT | KRKGSAGEGR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IFGSVSEAIM | AFDARDLHLN | SQVKIRLEGF | VPYSGWEAPE | GWEQGQPAIV | ETSLGQVLFN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ETLPADYPWV | EAVADKGELS | RIVNDLAERY | PKVVTAATLD | NLKDAGFYWA | TRSGVTVAIS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DIEVPAAKPE | ILAGYEERAA | KIQGQYDKGL | IDDDERRQEL | IEIWNKATND | IAAVMRESLS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| PMNTINRMVS | SGARGNWMQV | RQIAGIRGLV | ANPKGEIIPR | PIKSSYREGL | SVLEYFIATH |
| 850 | 860 | 870 | 880 | 890 | 900 |
| GARKGLADTA | LRTANSGYLT | RRLVDVSQDV | IVREEDCGTE | RGLVTPIAVA | DSNGELVLDE |
| 910 | 920 | 930 | 940 | 950 | 960 |
| NVENSAYART | LAVDVVDSEG | NVLAAAGTDC | GDVVIDELFK | AGITEVKVRS | VLTCESSVGT |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| CALCYGRSLA | TGKTVDIGEA | VGIIAAQSIG | EPGTQLTMRT | FHTGGAVSAG | GGDDITQGLP |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| RIQELFEART | PKGVAPIAEA | AGRITIEESE | RQMRLVITPD | DGTEEIAYPV | LRRSRLLIED |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| GDHVTVGQKL | INGPVDPKQV | LRIMGPRAAQ | KFLVDEVQGV | YRSQGIGIHD | KHVEVIVRQM |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| LRRVTVIESG | ESDLLPGELA | ERSRFEDANR | RVVSEGKAPA | SGRPELMGIT | KASLATESWL |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| SAASFQETTR | VLTQAAMEGK | SDPLLGLKEN | VIIGKLIPAG | TGLPRYTEVT | VEPTEEAKAN |
| 1270 | 1280 | 1290 | |||
| LFTGPSAFSD | FSYDTLGGDG | APEFHAIPLD | DYDLGNDFR |