B8GNX4

PR
Gene name
carA
Protein name
Carbamoyl-phosphate synthase small chain
Names
Carbamoyl-phosphate synthetase glutamine chain
Species
Thioalkalivibrio sulfidiphilus (strain HL-EbGR7)
KEGG Pathway
tgr:Tgr7_0975
EC number
6.3.5.5: Carbon--nitrogen ligases with glutamine as amido-N-donor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

145-216 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B8GNX4

Entry ID Method Resolution Chain Position Source
AF-B8GNX4-F1 Predicted AlphaFoldDB

No variants for B8GNX4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B8GNX4

No associated diseases with B8GNX4

14 regional properties for B8GNX4

Type Name Position InterPro Accession
domain Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain 128 - 334 IPR005479-1
domain Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain 686 - 892 IPR005479-2
domain Carbamoyl-phosphate synthetase, large subunit oligomerisation domain 427 - 549 IPR005480
domain Carbamoyl-phosphate synthase large subunit, CPSase domain 19 - 33 IPR005483-1
domain Carbamoyl-phosphate synthase large subunit, CPSase domain 48 - 58 IPR005483-2
domain Carbamoyl-phosphate synthase large subunit, CPSase domain 168 - 180 IPR005483-3
domain Carbamoyl-phosphate synthase large subunit, CPSase domain 204 - 223 IPR005483-4
domain Carbamoyl-phosphate synthase large subunit, CPSase domain 239 - 256 IPR005483-5
domain Carbamoyl-phosphate synthase large subunit, CPSase domain 297 - 326 IPR005483-6
domain Carbamoyl-phosphate synthase large subunit, CPSase domain 380 - 398 IPR005483-7
domain Methylglyoxal synthase-like domain 963 - 1099 IPR011607
domain ATP-grasp fold 133 - 328 IPR011761-1
domain ATP-grasp fold 691 - 887 IPR011761-2
domain Carbamoyl-phosphate synthase large chain, methylglyoxal synthase-like domain 969 - 1069 IPR033937

Functions

Description
EC Number 6.3.5.5 Carbon--nitrogen ligases with glutamine as amido-N-donor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate.

4 GO annotations of biological process

Name Definition
'de novo' pyrimidine nucleobase biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors.
'de novo' UMP biosynthetic process The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD(+) or oxygen.
arginine biosynthetic process The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNFTPALLAL EDGSLFHGIS IGAPGQTVGE VVFNTAMTGY QEILTDPSYA RQIVTLTYPH
70 80 90 100 110 120
IGNTGVNPED EESAGVHAAG LVIRDLPPLV SSWRSRESLP DYLTRFGVVA IANIDTRRLT
130 140 150 160 170 180
RILREKGAQN GCIMAGEIDE QAALAAARGF PGLKGMDLAK EVSTAEIYDW TEGTWQLGSG
190 200 210 220 230 240
HAPAPASSPY KVVAYDFGVK RNILRMLVDR GCQVTVVPAQ TPAAQVLAMQ PDGVFLSNGP
250 260 270 280 290 300
GDPEPCDYAI SAIREIVDTG IPTYGICLGH QLLGLASGAR TVKMKFGHHG ANHPVQDLDS
310 320 330 340 350 360
KRVMISSQNH GFAVDENTLP GNVKATHRSL FDGTLQGIAR TDRPAFSFQG HPEASPGPHD
370
VAPLFDRFIE LMKPQGVRK