B8F492

PR
Gene name
pnp
Protein name
Polyribonucleotide nucleotidyltransferase
Names
Polynucleotide phosphorylase, PNPase
Species
Glaesserella parasuis serovar 5 (strain SH0165) (Haemophilus parasuis)
KEGG Pathway
hap:HAPS_0476
EC number
2.7.7.8: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

357-430 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B8F492

Entry ID Method Resolution Chain Position Source
AF-B8F492-F1 Predicted AlphaFoldDB

No variants for B8F492

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B8F492

No associated diseases with B8F492

9 regional properties for B8F492

Type Name Position InterPro Accession
domain Exoribonuclease, phosphorolytic domain 1 15 - 143 IPR001247-1
domain Exoribonuclease, phosphorolytic domain 1 323 - 455 IPR001247-2
domain S1 domain 618 - 689 IPR003029
domain K Homology domain 551 - 616 IPR004087
domain K Homology domain, type 1 555 - 613 IPR004088
domain Exoribonuclease, phosphorolytic domain 2 146 - 209 IPR015847-1
domain Exoribonuclease, phosphorolytic domain 2 459 - 526 IPR015847-2
domain Polyribonucleotide nucleotidyltransferase, RNA-binding domain 241 - 319 IPR015848
domain RNA-binding domain, S1 619 - 689 IPR022967

Functions

Description
EC Number 2.7.7.8 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
magnesium ion binding Binding to a magnesium (Mg) ion.
polyribonucleotide nucleotidyltransferase activity Catalysis of the reaction: RNA(n+1) + phosphate <=> RNA(n) + a nucleoside diphosphate.
RNA binding Binding to an RNA molecule or a portion thereof.

2 GO annotations of biological process

Name Definition
mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTPIVKQFKY GQHTVTLETG AIARQATAAV MASMDDTTVF VTVVAKKEVN EGQDFFPLTV
70 80 90 100 110 120
DYQERTYAAG RIPGGFFKRE GRPSEGETLI ARLIDRPVRP LFPEGFFNEI QVIATVVSVN
130 140 150 160 170 180
PQISPDLVAM IGASAALSLS GVPFNGPIGA ARVGFIDNQF VLNPTTSEQR LSRLDLVVAG
190 200 210 220 230 240
TDKAVLMVES EADILTEEQM LAAVVFGHEQ QQVVIENIKE FVKEAGKPRW DWVAPEPNTD
250 260 270 280 290 300
LINKVKALAE ARLGDAYRIT EKQARYEQID AIKADVIAQL TAEDETISSG KIVDIITALE
310 320 330 340 350 360
SQIVRSRIIA GEPRIDGRTV DTVRALDICT GVLPRTHGSA LFTRGETQAL AVATLGTERD
370 380 390 400 410 420
AQIIDELTGE KSDRFLFHYN FPPYSVGETG RIGSPKRREI GHGRLAKRGV LAVMPTAEEF
430 440 450 460 470 480
PYVVRVVSEI TESNGSSSMA SVCGASLALM DAGVPIKAAV AGIAMGLVKE EEKFVVLSDI
490 500 510 520 530 540
LGDEDHLGDM DFKVAGTREG VTALQMDIKI EGITPEIMRI ALNQAKGARM HILGVMEQAI
550 560 570 580 590 600
PAPRSEISDF APRIHTMKID PKKIKDVIGK GGATIRALTE ETGTSIDIDD DGTVKIAATD
610 620 630 640 650 660
NNAAKRVMER IEEIVAEVEV NAIYKGKVTR VVDFGAFVSI LGGKEGLVHI SQITDARVER
670 680 690 700
VADYLSVGQD VQVKVVEIER QGRIRLTMKD LNGDATAREV VEEIQELAE