B8ER30

PR
Gene name
hisS
Protein name
Histidine--tRNA ligase
Names
Histidyl-tRNA synthetase, HisRS
Species
Methylocella silvestris (strain DSM 15510 / CIP 108128 / LMG 27833 / NCIMB 13906 / BL2)
KEGG Pathway
msl:Msil_0805
EC number
6.1.1.21: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-45 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B8ER30

Entry ID Method Resolution Chain Position Source
AF-B8ER30-F1 Predicted AlphaFoldDB

No variants for B8ER30

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B8ER30

No associated diseases with B8ER30

2 regional properties for B8ER30

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II 31 - 382 IPR006195
domain Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain 18 - 369 IPR041715

Functions

Description
EC Number 6.1.1.21 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
histidine-tRNA ligase activity Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).

1 GO annotations of biological process

Name Definition
histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTDDKTTPAR ASAKLPRGFG DRGPAEIAAT EKMLAAIRAS YELYGFEAVE TPFIEFTDAL
70 80 90 100 110 120
GKFLPDLDRP NEGVFSFKDD DESWLSLRYD LTAPLARFVA ENFDKLPKPY RSYRAGYVFR
130 140 150 160 170 180
NEKPGPGRFR QFMQFDADTV GAPSVAADAE MCMMAADTLE RLGVKRGDYV IKVNNRKVLD
190 200 210 220 230 240
GVLEAIGLGG EENAGRRMTV LRAIDKLDKF GPEGVALLLG PGRKDESGDF TKGAGLERTA
250 260 270 280 290 300
VERVLNYVAA QGEGTAQMLG VLRASVAGSQ RGEEGVAELA EIAALIDAAG FSARIRIDPS
310 320 330 340 350 360
VVRGLEYYTG PVFEAELTFE VQGEDGKPVR FGSIGGGGRY DGLVGRFRGE NVPATGFSIG
370 380 390 400 410 420
VSRLYSALKA VGSPIVSAAS QPGPVVVLVL DREHLARYQG FVTALRSADI RAELYLGGSG
430 440 450 460 470 480
MNAQLKYADK RGSLCAVIQG SNERDHAEGA RVTIRDLALG AELAGASKDR ADYLELRAKA
490 500
QFTVAEQNLV DAVREVMARR S