B8DZX8

PR
Gene name
lig
Protein name
Probable DNA ligase
Names
Polydeoxyribonucleotide synthase [ATP]
Species
Dictyoglomus turgidum (strain DSM 6724 / Z-1310)
KEGG Pathway
dtu:Dtur_0780
EC number
6.5.1.1: Forming phosphoric ester bonds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

87-157 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B8DZX8

Entry ID Method Resolution Chain Position Source
AF-B8DZX8-F1 Predicted AlphaFoldDB

No variants for B8DZX8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B8DZX8

No associated diseases with B8DZX8

5 regional properties for B8DZX8

Type Name Position InterPro Accession
domain DNA ligase, ATP-dependent, N-terminal 3 - 169 IPR012308
domain DNA ligase, ATP-dependent, C-terminal 447 - 552 IPR012309
domain DNA ligase, ATP-dependent, central 223 - 457 IPR012310
conserved_site DNA ligase, ATP-dependent, conserved site 243 - 251 IPR016059-1
conserved_site DNA ligase, ATP-dependent, conserved site 394 - 418 IPR016059-2

Functions

Description
EC Number 6.5.1.1 Forming phosphoric ester bonds
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA ligase (ATP) activity Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m).
metal ion binding Binding to a metal ion.

7 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
DNA biosynthetic process The biosynthetic process resulting in the formation of DNA.
DNA ligation The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase.
DNA recombination Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
lagging strand elongation The process in which an existing DNA strand is extended in a net 3' to 5' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLFGELAQYF EKIEKTTKRN EMMEILADLF KRVDKEEIEK IIYLLNGRVA PDYEKIEFGM
70 80 90 100 110 120
SEKLVLRAMA LALKVPIFDL EKVYKEVGDL GELIIKYSQN EGKDLTVVET FNTLFEIANL
130 140 150 160 170 180
SGEGSVDAKV NRLAFLINSL TPQGGKYLVR IVLGKLRLGV GEPTVMDALS FAKVKDKSLR
190 200 210 220 230 240
PFIERAFNIT SDLGYVAKVF WEGGIEALKK IKVEVGKPIR MALAERVSKV EEIVKRLGKC
250 260 270 280 290 300
AIEPKFDGFR CQIHKKENNV RIFSRNLEDN THMFPDLVEA VLKQFSDKNV IIEGEAISYN
310 320 330 340 350 360
PETGEFYPFQ VTVQRKRKYN ISEMVELYPL QLFAFDILYL NGEDITSLPY IRRRQKLEEA
370 380 390 400 410 420
ISEGEKIFVT KNIITNDPKE IQAFFEECIT EGLEGIVAKR LDAPYQAGIR NFNWIKLKRS
430 440 450 460 470 480
YQGHLADTVD CVILGYFKGR GHRAKFGIGA LLVGVYDDER DLFKTVAKIG TGPTEEEWVR
490 500 510 520 530 540
FREVLDEIKL ESKPNNVESL IEPDVWVEPK YVVVIQADEI TRSPVHTCGR ELDGLGYALR
550 560 570 580
FPRVIGFVRE DKGPYDATTV KEILEMFRGQ KKEKVEEDSD NL