B8CSC1

PR
Gene name
ileS
Protein name
Isoleucine--tRNA ligase
Names
Isoleucyl-tRNA synthetase, IleRS
Species
Shewanella piezotolerans (strain WP3 / JCM 13877)
KEGG Pathway
swp:swp_3728
EC number
6.1.1.5: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-73 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B8CSC1

Entry ID Method Resolution Chain Position Source
AF-B8CSC1-F1 Predicted AlphaFoldDB

No variants for B8CSC1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B8CSC1

No associated diseases with B8CSC1

3 regional properties for B8CSC1

Type Name Position InterPro Accession
conserved_site Twin-arginine translocation pathway, signal sequence 1 - 32 IPR006311
domain Glucan biosynthesis, periplasmic, MdoG C-terminal 45 - 534 IPR007444
conserved_site Twin-arginine translocation pathway, signal sequence, bacterial/archaeal 2 - 32 IPR019546

Functions

Description
EC Number 6.1.1.5 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
isoleucine-tRNA ligase activity Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDYKSTLNL PETEFPMRGN LANREPEMLK SWNEKGLYQQ IRESRKDSKP FILHDGPPYA
70 80 90 100 110 120
NGDIHIGHSV NKILKDIIIK SKTMSGFDAP YIPGWDCHGL PIELKVEQKV GKPGHKVTAS
130 140 150 160 170 180
EFRQKCREYA AKQVDGQRDD FIRLGVFADW QNPYLTMDYN TEANIVRSLS KVIDSGHLHK
190 200 210 220 230 240
GVKPVHWCTD CGSALAEAEV EYEDKMSPAI DVAFTAVDKP ALLAKFGLTE YAHPISMVIW
250 260 270 280 290 300
TTTPWTLPAN RALSVAGQLE YTLVEMVKDG QTQALVLAQE LVESCVERFG AETHKVLANV
310 320 330 340 350 360
LGSELELLRF NHPFYDFDVP VILGEHVTVE SGTGVVHTAP GHGQDDFVVG QKYGLEVANP
370 380 390 400 410 420
VGDNGVYKAD TEIFAGQHVF KANKAVVALL EEKGALLNHV AINHSYPHCW RHKTPIIFRA
430 440 450 460 470 480
TPQWFISMDQ KGLRTQALSE IEKTQWIPDW GQSRIEKMVE NRPDWCISRQ RTWGVPITLF
490 500 510 520 530 540
VHRETEELHP DSVSLMERVA NRIEQEGIQA WWDLDAAELL GDEAEQYRKV TDTLDVWYDS
550 560 570 580 590 600
GSTFSSVVAS RPEFNGHEVD LYLEGSDQHR GWFMSSLMIS TAMNGKAPYK QVLTHGFTVD
610 620 630 640 650 660
GKGRKMSKSV GNVIAPQHVT NKLGADILRL WVAATDYSGE MTVSDEILKR SADAYRRIRN
670 680 690 700 710 720
TARFLLANIN GFNPETDMVA VEDMVALDRW VVRRAAALQQ ELLEAYDQYN FHLVTQKLMQ
730 740 750 760 770 780
FCSVELGSFY LDIIKDRQYT AKDDSNARRS CQSALYLISE AMVRWIAPVL SFTADEIWKL
790 800 810 820 830 840
LPGERGEFVF TETWYEGLQS VTLDSDLSDE FWEQLLTVRA EVNKVIENAR REKQIGGSLE
850 860 870 880 890 900
AEIMLFADEA LSTALSTLGD ELRFVLLTSK TDVVALSEAP ADAIETELAS LKLGLKKSEA
910 920 930
EKCERCWHHR EEVGQVAEHP TLCTRCVTNI EGEGETRQFA