B7ZR30
Gene name |
stk10-a (plkk1) |
Protein name |
Serine/threonine-protein kinase 10-A |
Names |
Polo-like kinase kinase 1, XPlkk1 |
Species |
Xenopus laevis (African clawed frog) |
KEGG Pathway |
xla:373731 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
174-197 (Activation loop from InterPro)
Target domain |
23-314 (Catalytic domain of the Serine/Threonine Kinase, STK10, also called Lymphocyte-Oriented Kinase or LOK) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for B7ZR30
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B7ZR30-F1 | Predicted | AlphaFoldDB |
No variants for B7ZR30
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for B7ZR30 | |||||
No associated diseases with B7ZR30
4 regional properties for B7ZR30
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 36 - 294 | IPR000719 |
| active_site | Serine/threonine-protein kinase, active site | 153 - 165 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 42 - 65 | IPR017441 |
| domain | Serine/threonine-protein kinase 10, catalytic domain | 23 - 314 | IPR042743 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| G2/M transition of mitotic cell cycle | The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex. |
| oocyte maturation | A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| regulation of lymphocyte migration | Any process that modulates the frequency, rate or extent of lymphocyte migration. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAFANFRRIL | RLPNFEKKRL | REYEHVRRDV | DPNQVWEIIG | ELGDGAFGKV | YKAKNRETGI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LAAAKVIETK | NEEELEDYMV | EIEILATCNH | HFIVKLLGAF | YWEGKLWIMI | EFCPGGAVDA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VMLELDRGLK | EPEIKTICRQ | MLEALAYLHS | MKIIHRDLKA | GNVLLTLDGD | IKLADFGVSA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KNVKTLQRRD | SFIGTPYWMA | PEVVMCETMK | DAPYDYKADI | WSLGITLIEM | AQIEPPHHEL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NPMRVLLKIA | KSEPPTLSSL | SKWSPEFHSF | LKTALDKNPE | TRPSAAQLLE | HPFVKKASGN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KPLRDLVAEA | KAEVLDEIEE | QGEAEEEEDS | DMLSPKTKGV | SQSTHVEIGK | DIEREQVGNG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IKPHSATSPQ | KTDSQADNYS | QRRNNEVKNC | PENGRPDAVN | GKPDIIILNP | LSSNLEPKRN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| STAESYRGEE | HSSASSQRQR | SAQSAELVPN | GSFDSPTRYF | TNWSKRDSDS | GSNSASESMD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ISMNLSADLS | MNKETGFLSH | RENRLHKKTL | KRTRRFVVDG | VEVSITTSKI | IGDDEKKDEE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| MRFLRRQELR | ELRLLQKEEH | RHQAQLTSKH | SFQLEQMSRR | FEQEMNSKRK | FYDTELETLE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RHQKQQIVWM | EQEHAFRRRD | EAKHIKTEQE | RDHIKFLEQL | KLRKKELKAH | VEKLPRQQRR |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ETMKVQMDGF | AHKKQTEEQQ | FVNRQKEDLN | LAMRVIVLEN | RKEIYNKERE | FLNKKQQLLR |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DRESVIWELE | ERHLQERHQL | VKQQLKDQYF | LQRHELLRKH | EKEQEQMQRY | NQRMMEQLRL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RQQQEKVRLP | KNQKAEAKTR | MTMFKKSLHI | SPSGSAAEQR | DKIKQFSLQE | EKRQKAERLQ |
| 850 | 860 | 870 | 880 | 890 | 900 |
| QQQKHEHQLM | EMLAECDCNV | RDLLQMQNEK | CHLLVEHETQ | KLKSLDEHHI | QLIREWRENI |
| 910 | 920 | 930 | 940 | ||
| RPRKKAFEDE | LELKKEAQEM | FFRLNEEVAG | DPFLSNKPTR | FYSFSSPEAS |