B7VAU6

PR
Gene name
metE
Protein name
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
Names
Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme
Species
Pseudomonas aeruginosa (strain LESB58)
KEGG Pathway
pag:PLES_33961
EC number
2.1.1.14: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

349-490 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B7VAU6

Entry ID Method Resolution Chain Position Source
AF-B7VAU6-F1 Predicted AlphaFoldDB

No variants for B7VAU6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B7VAU6

No associated diseases with B7VAU6

2 regional properties for B7VAU6

Type Name Position InterPro Accession
domain Cobalamin-independent methionine synthase MetE, C-terminal/archaeal 435 - 758 IPR002629
domain Cobalamin-independent methionine synthase MetE, N-terminal 4 - 317 IPR013215

Functions

Description
EC Number 2.1.1.14 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
methylation The process in which a methyl group is covalently attached to a molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MALAHTLGFP RIGRDRELKK AQEAFWKGEL DEAGLRAVGR QLRAAHWQVQ KDAGIQLLPV
70 80 90 100 110 120
GDFAWYDQVL THSLTFGVIP ERFRAHGEAG PTLHTLFGMA RGVSDDSCCG GAHAQEMTKW
130 140 150 160 170 180
FDTNYHYLVP EFSADQQFQL SWEQLFEEVD EARALGHQVK PVLIGPLTYL WLGKGKGAEF
190 200 210 220 230 240
DRLDLLDRLL PLYGQILRRL AGQGVEWVQI DEPILVLDLP QAWKNAFERA YNLLQSEPLK
250 260 270 280 290 300
KLVATYFGGL EDNLGLAANL PVDGLHIDLV RAPEQYPSIL DRLPAYKVVS LGLVNGRNVW
310 320 330 340 350 360
RCDLEKALEV VRHARERLGE RLWVAPSCSL LHSPVDLERE DGLDAELKSW LAFAVQKCRE
370 380 390 400 410 420
VAVLARAATE PEAAEVLAAL EESRAVQASR ASSPRIHKPA VQARLAAIKA SDAQRRSPFA
430 440 450 460 470 480
ERIARQRAGL DLPAFPTTTI GSFPQTSSIR LARQSFKQGK LSEAEYIEAM HSEIRHAVQI
490 500 510 520 530 540
QEQLGLDVLV HGEAERNDMV EYFAEQLDGY VFTRFGWVQS YGSRCVKPAV IYGDLSRPRA
550 560 570 580 590 600
MTVEWIRYAQ SLTDKVMKGM LTGPVTMLMW SFPREDVSRE VQARQLALAI RDEVVDLEAA
610 620 630 640 650 660
GIRIVQIDEA AFREGLPLRR NAWPHYLEWA TEAFRLCASG VRDETQIHTH MCYSEFNDVI
670 680 690 700 710 720
ESIAAMDADV ITIETSRSDM ELLEAFEQFD YPNEIGPGVY DIHSPRVPSR EEIVALLRKA
730 740 750 760
ARRIPAERLW VNPDCGLKTR AWPETEAALV NMVAAARELR GDLARG