B7VA96

PR
Gene name
hmgA
Protein name
Homogentisate 1,2-dioxygenase
Names
HGDO, Homogentisate oxygenase, Homogentisic acid oxidase, Homogentisicase
Species
Pseudomonas aeruginosa (strain LESB58)
KEGG Pathway
pag:PLES_33141
EC number
1.13.11.5: With incorporation of two atoms of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-55 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B7VA96

Entry ID Method Resolution Chain Position Source
AF-B7VA96-F1 Predicted AlphaFoldDB

No variants for B7VA96

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B7VA96

No associated diseases with B7VA96

2 regional properties for B7VA96

Type Name Position InterPro Accession
domain Homogentisate 1,2-dioxygenase, C-terminal domain 277 - 429 IPR046451
domain Homogentisate 1,2-dioxygenase, N-terminal domain 12 - 276 IPR046452

Functions

Description
EC Number 1.13.11.5 With incorporation of two atoms of oxygen
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
homogentisate 1,2-dioxygenase activity Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+).
iron ion binding Binding to an iron (Fe) ion.

2 GO annotations of biological process

Name Definition
L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid.
tyrosine catabolic process The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNLDSTALAY QSGFGNEFSS EALPGALPVG QNSPQKAPYG LYAELLSGTA FTMARSEARR
70 80 90 100 110 120
TWLYRITPSA KHPPFRRLER QIAGAELDAP TPNRLRWDPL ALPEQPTDFL DGLLRMAANA
130 140 150 160 170 180
PGDKPAGVSI YQYLANRSME RCFYDADGEL LLVPQLGRLR LCTELGALQV EPLEIAVIPR
190 200 210 220 230 240
GMKFRVELLD GEARGYIAEN HGAPLRLPDL GPIGSNGLAN PRDFLTPVAR YEDSRQPLQL
250 260 270 280 290 300
VQKYLGELWA CELDHSPLDV VAWHGNNVPY KYDLRRFNTI GTVSFDHPDP SIFTVLTSPT
310 320 330 340 350 360
SVPGLANIDF VIFPPRWMVA ENTFRPPWFH RNLMNEFMGL IQGAYDAKAG GFVPGGASLH
370 380 390 400 410 420
SCMSAHGPDA ESCDKAIAAD LKPHRIDQTM AFMFETSQVL RPSRAALETP ALQNDYDACW
430
ASLVSTFNPQ RR