B7PS00

PR
Gene name
IscW_ISCW007420
Protein name
Lissencephaly-1 homolog
Names
Species
Ixodes scapularis (Black-legged tick) (Deer tick)
KEGG Pathway
isc:IscW_ISCW007420
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-67 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B7PS00

Entry ID Method Resolution Chain Position Source
AF-B7PS00-F1 Predicted AlphaFoldDB

No variants for B7PS00

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B7PS00

No associated diseases with B7PS00

11 regional properties for B7PS00

Type Name Position InterPro Accession
repeat WD40 repeat 95 - 260 IPR001680-1
repeat WD40 repeat 263 - 411 IPR001680-2
domain LIS1 homology motif 7 - 39 IPR006594
conserved_site WD40 repeat, conserved site 163 - 177 IPR019775-1
conserved_site WD40 repeat, conserved site 205 - 219 IPR019775-2
conserved_site WD40 repeat, conserved site 312 - 326 IPR019775-3
conserved_site WD40 repeat, conserved site 354 - 368 IPR019775-4
conserved_site WD40 repeat, conserved site 396 - 410 IPR019775-5
repeat G-protein beta WD-40 repeat 121 - 135 IPR020472-1
repeat G-protein beta WD-40 repeat 312 - 326 IPR020472-2
repeat G-protein beta WD-40 repeat 354 - 368 IPR020472-3

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Localizes to the plus end of microtubules and to the centrosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
axon cytoplasm Any cytoplasm that is part of a axon.
cytoplasmic microtubule Any microtubule in the cytoplasm of a cell.
kinetochore A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
microtubule associated complex Any multimeric complex connected to a microtubule.
microtubule organizing center An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).

2 GO annotations of molecular function

Name Definition
dynein complex binding Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity.
microtubule plus-end binding Binding to the plus end of a microtubule.

9 GO annotations of biological process

Name Definition
brain morphogenesis The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
establishment of mitotic spindle orientation A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
germ cell development The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
microtubule organizing center organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow.
microtubule sliding The movement of one microtubule along another microtubule.
nuclear migration The directed movement of the nucleus to a specific location within a cell.
retrograde axonal transport The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons.
vesicle transport along microtubule The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVLSQRQREE LNKAIADYLA SNGFMEALES FKKETDMPGD IDKKYAGLLE KKWTSVIRLQ
70 80 90 100 110 120
KKVMDLEGRL AEAEKEYISG TPSREKRSPT EWIPRPPERS ALLGHRAPIT RVLFHPVYSV
130 140 150 160 170 180
VVSASEDASI KVWDYETGDF ERTIKGHTDS VQDIAFDHTG QFLASCSADM TIKLWDFKSY
190 200 210 220 230 240
ECLRTMHGHD HNVSSVCFLP SGDHVVSCSR DKSIKMWEVA TGYCVRTFTG HRDWVRMVRV
250 260 270 280 290 300
NSDGSLLASC SNDQTVRVWV VGTKECKLEL REHDHVVECV AWAPAHAQLC GAAGDSNRRP
310 320 330 340 350 360
GAGGAQGTGP FLVSGSRDKT IKVWDVSTGL ALFTLVGHDN WVRGVKFHPG GKYLLSASDD
370 380 390 400 410
KTLRVWELAH QRCCKTLDAH SHFCTSLDFH RTAPYVVTGS VDQTVKVWEC R