B7MAD3

PR
Gene name
cca
Protein name
Multifunctional CCA protein
Names
Species
Escherichia coli O45:K1 (strain S88 / ExPEC)
KEGG Pathway
ecz:ECS88_3454
EC number
2.7.7.72: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

58-213 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B7MAD3

Entry ID Method Resolution Chain Position Source
AF-B7MAD3-F1 Predicted AlphaFoldDB

No variants for B7MAD3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B7MAD3

No associated diseases with B7MAD3

4 regional properties for B7MAD3

Type Name Position InterPro Accession
domain Poly A polymerase, head domain 1 - 122 IPR002646
domain HD/PDEase domain 227 - 343 IPR003607
domain HD domain 228 - 329 IPR006674
domain tRNA nucleotidyltransferase/poly(A) polymerase, RNA and SrmB- binding domain 150 - 212 IPR032828

Functions

Description
EC Number 2.7.7.72 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

9 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity Catalysis of the reaction: a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate.
CTP:3'-cytidine-tRNA cytidylyltransferase activity Catalysis of the reaction: a tRNA with a 3' cytidine + CTP = a tRNA with a 3' CC end + diphosphate.
CTP:tRNA cytidylyltransferase activity Catalysis of the reaction: a tRNA precursor + CTP = a tRNA with a 3' cytidine end + diphosphate.
cyclic-nucleotide phosphodiesterase activity Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate.
magnesium ion binding Binding to a magnesium (Mg) ion.
phosphatase activity Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
tRNA binding Binding to a transfer RNA.
tRNA cytidylyltransferase activity Catalysis of the reaction: CTP + tRNA(n) = diphosphate + tRNA(n+1).

2 GO annotations of biological process

Name Definition
RNA repair Any process that results in the repair of damaged RNA.
tRNA 3'-terminal CCA addition Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript. CCA addition proceeds by the sequential addition of CTP, CTP, and then ATP to the 3' end of the tRNA, yielding a diphosphate with each nucleotide addition.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKIYLVGGAV RDALLGLPVK DRDWVVVGST PQEMLDAGYQ QVGRDFPVFL HPQTHEEYAL
70 80 90 100 110 120
ARTERKSGSG YTGFTCYAAP DVTLEDDLKR RDLTINALAQ DDNGEIIDPY NGLGDLQNRL
130 140 150 160 170 180
LRHVSPAFGE DPLRVLRVAR FAARYAHLCF RIADETLALM REMTHAGELE HLTPERVWKE
190 200 210 220 230 240
TENALTTRNP QVFFQVLRDC GALRVLFPEI DALFGVPAPA RWHPEIDTGI HTLMTLSMAA
250 260 270 280 290 300
MLSPQVDVRF ATLCHDLGKG LTPPELWPRH HGHGPAGVKL VEQLCQRLRV PNEIRDLARL
310 320 330 340 350 360
VAEFHDLIHT FPMLNPKTIV KLFDSIDAWR KPQRVEQLAL TSEADVRGRT GFESADYPQG
370 380 390 400 410
RWLREAWEVA QSVPTKAVVE AGFKGVEIRE ELTRRRIAAV AGWKEQRCPK PE