B7LV66
Gene name |
thiM |
Protein name |
Hydroxyethylthiazole kinase |
Names |
4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase |
Species |
Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73) |
KEGG Pathway |
efe:EFER_2190 |
EC number |
2.7.1.50: Phosphotransferases with an alcohol group as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B7LV66
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B7LV66-F1 | Predicted | AlphaFoldDB |
No variants for B7LV66
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for B7LV66 | |||||
No associated diseases with B7LV66
8 regional properties for B7LV66
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Aspartate/glutamate/uridylate kinase | 3 - 283 | IPR001048 |
| domain | Aspartate kinase | 4 - 459 | IPR001341 |
| domain | Homoserine dehydrogenase, catalytic | 613 - 810 | IPR001342 |
| domain | ACT domain | 319 - 400 | IPR002912 |
| domain | Aspartate/homoserine dehydrogenase, NAD-binding | 471 - 605 | IPR005106 |
| conserved_site | Aspartate kinase, conserved site | 3 - 11 | IPR018042 |
| conserved_site | Homoserine dehydrogenase, conserved site | 659 - 681 | IPR019811 |
| domain | Bifunctional aspartokinase/homoserine dehydrogenase, N-terminal catalytic domain | 1 - 295 | IPR041743 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.1.50 | Phosphotransferases with an alcohol group as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| hydroxyethylthiazole kinase activity | Catalysis of the reaction: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP + 2 H(+). |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| thiamine biosynthetic process | The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. |
| thiamine diphosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQPDLLSRKT | AALTLQKFHT | LSPLTHCMTN | DVVQTFTANT | LLALGASPAM | VIETEEASQF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AAVASALLIN | VGTLTQARAH | AMRAAVVHAK | RVKTPWTLDP | VAVGSLDYRR | HFCTELLSLN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PDAIRGNASE | IMALAGVSNS | GRGVDSTDVV | ANALPAAVML | AQETGAVVVV | TGEVDYVTDG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RRTVGVGGGD | PLMTKVVGTG | CALSAVVAAC | CALPGDRLLN | VASACSWMKQ | AGERAIVRSQ |
| 250 | 260 | ||||
| GPGTFVPYFL | DALWQMTQEV | EA |