B7LUN5

PR
Gene name
argH
Protein name
Argininosuccinate lyase
Names
ASAL, Arginosuccinase
Species
Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)
KEGG Pathway
efe:EFER_3803
EC number
4.3.2.1: Lyases acting on amides, amidines, etc
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

397-457 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B7LUN5

Entry ID Method Resolution Chain Position Source
AF-B7LUN5-F1 Predicted AlphaFoldDB

No variants for B7LUN5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B7LUN5

No associated diseases with B7LUN5

3 regional properties for B7LUN5

Type Name Position InterPro Accession
conserved_site Fumarate lyase, conserved site 276 - 285 IPR020557
domain Fumarate lyase, N-terminal 6 - 301 IPR022761
domain Argininosuccinate lyase, C-terminal 364 - 431 IPR029419

Functions

Description
EC Number 4.3.2.1 Lyases acting on amides, amidines, etc
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
argininosuccinate lyase activity Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine.

1 GO annotations of biological process

Name Definition
arginine biosynthetic process via ornithine The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MALWGGRFTQ AADQRFKQFN DSLRFDYRLA EQDIVGSVAW SKALVTVGVL TAEEQVQLEE
70 80 90 100 110 120
ALNVLLEDVR ARPQQILESD AEDIHSWVEG KLIDKVGQLG KKLHTGRSRN DQVATDLKLW
130 140 150 160 170 180
CKDTVSELLT ANRQLQSALV ETAENNQDAV MPGYTHLQRA QPVTFAHWCL AYVEMLARDE
190 200 210 220 230 240
SRLQDALKRL DVSPLGCGAL AGTAYEIDRE QLAGWLGFAS ATRNSLDSVS DRDHVLELLS
250 260 270 280 290 300
AAAIGMVHLS RFAEDLIFFN TGEAGFVELS DRVTSGSSLM PQKKNPDALE LIRGKCGRVQ
310 320 330 340 350 360
GALTGMMMTL KGLPLAYNKD MQEDKEGLFD ALDTWLDCLH MAALVLDGIQ VKRPRCQEAA
370 380 390 400 410 420
QQGYANATEL ADYLVAKGVP FREAHHIVGE AVVEAIRQGK PLEELPLSEL QKFSQVIGED
430 440 450
VYPILSLQSC LDKRAAKGGV SPQQVAQAIA FAQARLG