B7LKC4

PR
Gene name
hisS
Protein name
Histidine--tRNA ligase
Names
Histidyl-tRNA synthetase, HisRS
Species
Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)
KEGG Pathway
efe:EFER_0658
EC number
6.1.1.21: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

377-429 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B7LKC4

Entry ID Method Resolution Chain Position Source
AF-B7LKC4-F1 Predicted AlphaFoldDB

No variants for B7LKC4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B7LKC4

No associated diseases with B7LKC4

4 regional properties for B7LKC4

Type Name Position InterPro Accession
domain Anticodon-binding 343 - 425 IPR004154
domain Aminoacyl-tRNA synthetase, class II 1 - 332 IPR006195
domain Histidyl-anticodon-binding 333 - 425 IPR033656
domain Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain 10 - 322 IPR041715

Functions

Description
EC Number 6.1.1.21 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
histidine-tRNA ligase activity Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).

1 GO annotations of biological process

Name Definition
histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSKKIQSVRG MNDYLPVETA VWQRVERIIK SVVESYGYSE IRTPILEQTP LFKRAIGEVT
70 80 90 100 110 120
DVVEKEMYTF NDRERDAKEV VSLTLRPEGT AGCVRAGIEH GLLYNQEQRL WYMGPMFRHE
130 140 150 160 170 180
RPQKGRYRQF HQIGLEVFGL QGPDIDAELI MLTARWWREL GISEHVTLEL NSIGSLEARA
190 200 210 220 230 240
NYRDALVAFL EQHKEKLDED CKRRMYTNPL RVLDSKNPEV QALLNDAPAL GDYLDEESRE
250 260 270 280 290 300
HFAGLCKLLE SAGIAYTVNQ RLVRGLDYYN RTVFEWVTNS LGSQGTVCAG GRYDGLVEQL
310 320 330 340 350 360
GGRATSAVGF AMGLERLVLL VQAVNPEFKA DPVVDIYLVA SGADTQPAAM ALAERLRDEL
370 380 390 400 410 420
PGVKLMTNHG GGNFKKQFGR ADKWGARIAV VLGESEVANG TAVVKDLRSG EQTAVAQDSV
AAHLRTLLG