B7L9X5

PR
Gene name
thiM
Protein name
Hydroxyethylthiazole kinase
Names
4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase
Species
Escherichia coli (strain 55989 / EAEC)
KEGG Pathway
eck:EC55989_2359
EC number
2.7.1.50: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

21-183 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B7L9X5

Entry ID Method Resolution Chain Position Source
AF-B7L9X5-F1 Predicted AlphaFoldDB

No variants for B7L9X5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B7L9X5

No associated diseases with B7L9X5

3 regional properties for B7L9X5

Type Name Position InterPro Accession
domain MIF4G-like, type 3 31 - 243 IPR003890
domain MIF4G-like, type 1 349 - 473 IPR015172
domain MIF4G-like, type 2 488 - 770 IPR015174

Functions

Description
EC Number 2.7.1.50 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
hydroxyethylthiazole kinase activity Catalysis of the reaction: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP + 2 H(+).
magnesium ion binding Binding to a magnesium (Mg) ion.

3 GO annotations of biological process

Name Definition
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
thiamine biosynthetic process The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.
thiamine diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQVDLLSSAQ SAHALHLFHQ HSPLVHCMTN DVVQTFTANT LLALGASPAM VIETEEASQF
70 80 90 100 110 120
AAIASALLIN VGTLTQPRAQ AMRAAVEQAK SSQTPWTLDP VAVGALDYRR HFCHELLSFK
130 140 150 160 170 180
PAAIRGNASE IMALAGIANG GRGVDTTDAA ANAIPAAQTL ARETGAIVVV TGEVDYVTDG
190 200 210 220 230 240
HRAVGIHGGD PLMTKVVGTG CALSAVVAAC CALPGDTLEN VASACHWMKQ AGERAVARSE
250 260
GPGSFVPHFL DALWQLTQEV QA