B7K9K1

PR
Gene name
proS
Protein name
Proline--tRNA ligase
Names
Prolyl-tRNA synthetase, ProRS
Species
Gloeothece citriformis (strain PCC 7424) (Cyanothece sp. (strain PCC 7424))
KEGG Pathway
cyc:PCC7424_1529
EC number
6.1.1.15: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

208-287 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B7K9K1

Entry ID Method Resolution Chain Position Source
AF-B7K9K1-F1 Predicted AlphaFoldDB

No variants for B7K9K1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B7K9K1

No associated diseases with B7K9K1

7 regional properties for B7K9K1

Type Name Position InterPro Accession
domain Cro/C1-type helix-turn-helix domain 253 - 279 IPR001387
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 97 - 486 IPR002314
domain Anticodon-binding 505 - 594 IPR004154
domain Aminoacyl-tRNA synthetase, class II 33 - 496 IPR006195
domain YbaK/aminoacyl-tRNA synthetase-associated domain 259 - 316 IPR007214
domain Prokaryote proline-tRNA ligase core domain 17 - 218 IPR033730
domain Proline--tRNA ligase, anticodon binding domain 501 - 593 IPR044140

Functions

Description
EC Number 6.1.1.15 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
proline-tRNA ligase activity Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).

1 GO annotations of biological process

Name Definition
prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. The prolyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a methionine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRLSQMLFVT LREDPAEAEI PSHKLLLRAG YIRRIGSGIY AYLPLMWRVL QKVSQIVRQE
70 80 90 100 110 120
MNATGAQECL LPQLQPSELW KESGRWDTYT KAEGIMFALE DRQERELGLG PTHEEVITFI
130 140 150 160 170 180
AREMIRSYRQ LPVNLYQIQT KFRDEIRPRF GLMRGREFIM KDAYSFDTDP EGLKKTYQDM
190 200 210 220 230 240
DKAYRNILRR CGLAFRAVDA DSGAIGGSGS QEFMVLADAG EDEVLYTDDG KYAANVEKAV
250 260 270 280 290 300
SLPPDEEPSP FKNYEKRETP NTDTIEKLAQ FLKCSPTVVV KNILYEAVYD NGMIVLVLVN
310 320 330 340 350 360
IRGDQEVNEV KLQNELVKLA PQYHAKTIIA LKVPDESAQQ KWAAKSLPLG YISPDLGDDY
370 380 390 400 410 420
IQGSKEIASK FVRLVDKTVV ELKNFVTGAN EKGYHVLGAN WGKEFKLPQL IVDVRTAKAG
430 440 450 460 470 480
DRAVHDRTQT LQSARGIEVG HIFQLGTKYS HAMGATYTNE QGEEMPLVMG CYGIGVSRLA
490 500 510 520 530 540
QSAVEQSYDK DGIIWPVAIA PYHAIVVIPN INDPQQVEVA EKLYTELNAA GIETLLDDRD
550 560 570 580 590
ERAGVKFKDS ELVGIPYRIV TGRSLKEGKL EVVERATKKS QDIPIDEVVS TIQQWVKAAL