B7K8U0

PR
Gene name
ligA
Protein name
DNA ligase
Names
Polydeoxyribonucleotide synthase [NAD(+)]
Species
Gloeothece citriformis (strain PCC 7424) (Cyanothece sp. (strain PCC 7424))
KEGG Pathway
cyc:PCC7424_2883
EC number
6.5.1.2: Forming phosphoric ester bonds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

559-678 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B7K8U0

Entry ID Method Resolution Chain Position Source
AF-B7K8U0-F1 Predicted AlphaFoldDB

No variants for B7K8U0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B7K8U0

No associated diseases with B7K8U0

10 regional properties for B7K8U0

Type Name Position InterPro Accession
domain BRCT domain 598 - 678 IPR001357
domain Helix-hairpin-helix DNA-binding motif, class 1 449 - 468 IPR003583-1
domain Helix-hairpin-helix DNA-binding motif, class 1 483 - 502 IPR003583-2
domain Helix-hairpin-helix DNA-binding motif, class 1 547 - 566 IPR003583-3
domain Zinc-finger, NAD-dependent DNA ligase C4-type 411 - 437 IPR004149
domain NAD-dependent DNA ligase, OB-fold 326 - 401 IPR004150
domain NAD-dependent DNA ligase, adenylation 7 - 322 IPR013839
domain NAD-dependent DNA ligase, N-terminal 7 - 451 IPR013840
active_site NAD-dependent DNA ligase, active site 119 - 148 IPR018239
domain DisA/LigA, helix-hairpin-helix motif 513 - 576 IPR041663

Functions

Description
EC Number 6.5.1.2 Forming phosphoric ester bonds
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA ligase (NAD+) activity Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m).
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPSATPEIKQ RVDQLRSQLQ KASYAYYVLD NPIMEDVVYD QLYRELQNIE TQYPELITPD
70 80 90 100 110 120
SPTQRVGDKL SEQFISVNHN IPLYSLENAF NLQEFARWQE RWQRLTPDVT QFEYVCELKI
130 140 150 160 170 180
DGSAIALTYE NGLLVRGVTR GDGIVGEEIT PNIKTIRSIP LKLALDNPPV RIEVRGEAFL
190 200 210 220 230 240
PIEEFERINQ EKQTAGESLF ANPRNAAAGT LRQLDPRIVD RRRLQFFAYT LYVIDSPSTP
250 260 270 280 290 300
TTQWESLEDL QQMGFLVNPN RKLCQSEAEV DQYYQLWDTE RHNLPYMTDG VVVKLNDYQL
310 320 330 340 350 360
QQQLGFTQKF PRWAIALKYP AEEAPTQVKN ITVNVGRTGA VTPMAIMEPV QLAGTTVQKA
370 380 390 400 410 420
TLHNSDRVAQ LDIRVGDTVI IRKAGEIIPE VVRVIEELRP PNTQPYQMPT QCPECHSTLV
430 440 450 460 470 480
RPKGEAVTRC VNSSCPAILR GSLVHWCSRD ALDIRGLGEK VVILLIDNGL VHSIADLYHL
490 500 510 520 530 540
KVEQIASLER MGTKSANNLI NAINKSKQQP WSRVLYGLGI RYVGSVTAKL LSDNFKSVEQ
550 560 570 580 590 600
LSQASFTSLE SVYGIGAEIA QSVYDWFKIE ANQTLIKNLQ QAELQFETLS ETPKYPPISS
610 620 630 640 650 660
TPLAGKTVVI TGTLPSLKRN EAQELIEKAG GKVTNSVSSK TDYLLVGEDA GSKLTKAQQL
670
GISQLSEEQL LKMINPQE