B7JYA9

PR
Gene name
leuS
Protein name
Leucine--tRNA ligase
Names
Leucyl-tRNA synthetase, LeuRS
Species
Rippkaea orientalis (strain PCC 8801) (Cyanothece sp (strain PCC 8801))
KEGG Pathway
cyp:PCC8801_3236
EC number
6.1.1.4: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-57 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B7JYA9

Entry ID Method Resolution Chain Position Source
AF-B7JYA9-F1 Predicted AlphaFoldDB

No variants for B7JYA9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B7JYA9

No associated diseases with B7JYA9

6 regional properties for B7JYA9

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 42 - 53 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 421 - 577 IPR002300-1
domain Aminoacyl-tRNA synthetase, class Ia 617 - 657 IPR002300-2
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 696 - 817 IPR013155
domain Methionyl/Leucyl tRNA synthetase 40 - 173 IPR015413
domain Leucyl-tRNA synthetase, editing domain 222 - 407 IPR025709

Functions

Description
EC Number 6.1.1.4 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
leucine-tRNA ligase activity Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu).

1 GO annotations of biological process

Name Definition
leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MESQYNAAAI EQKWQQDWVK QGLDKTPENS NKPKFYALSM FPYPSGNLHM GHVRNYVITD
70 80 90 100 110 120
VIARLKRLQG YRVLHPMGWD AFGLPAENAA IDRGIPPAEW TYKNMSQMKQ QLQTLGLSID
130 140 150 160 170 180
WEREVATCAP EYYKWTQWLF LQLYQAGLAY QKEAAVNWDP IDQTVLANEQ VDSEGYSWRS
190 200 210 220 230 240
GAKVERKLLR QWFLKITDYA EQLLTDLDKL PGWPDRVKLM QENWIGKSVG AYLEFPIKGS
250 260 270 280 290 300
EEKIAVFTTR PDTVYGVTYV VLAPEHPLTL KVTTPEQKAA VDAFIEEVSN ESEIERTAED
310 320 330 340 350 360
KPKRGILTGG TAINPFNGQE IPILIADYVL YEYGTGAVMG VPAHDTRDFK FAKEKQLPIK
370 380 390 400 410 420
VVIIPENSDN TNPPLTEAYT DPGIMVNSGI FDGIQSTEGK TAIIEYAEKE GYGKARIQYR
430 440 450 460 470 480
LRDWLISRQR YWGCPIPVVH CPSCGTVAVP DADLPVKLPE NVEFTGRDAS PLAKLEDWIN
490 500 510 520 530 540
VPCPSCGEPA KRETDTMDTF IDSSWYYLRY TDANNNQEAF NLEKANDWMA IDQYVGGIEH
550 560 570 580 590 600
AILHLLYSRF FTKALRDRGL VNIDEPFKRL LTQGMVQGLT YKNPQTGKYV PSENVIFQDD
610 620 630 640 650 660
HYRDKETGEI LSFFYEKMSK SKYNGVDPKQ VLGKYGADTA RMFILFKAPP EKDLEWDDAD
670 680 690 700 710 720
VEGQFRFLNR VWRLVANYLE NKPKTVKKAS ELTKEDKDLR RAIHTAIKEI SEDLEGDYQF
730 740 750 760 770 780
NTAVSELMKL SNALTDAKCL ESGVYQEGIE TLLILLAPFA PHIAEELWHN LGYEKSIHLQ
790 800 810 820 830 840
SWPTVNPDAL VVDEITLVIQ IMGKTRGTIQ VSATATKDEL EKLARESEVG QRYLDGQDVK
850
KVIVVPGKLV NFVIAK