B7GK53

PR
Gene name
leuS
Protein name
Leucine--tRNA ligase
Names
Leucyl-tRNA synthetase, LeuRS
Species
Anoxybacillus flavithermus (strain DSM 21510 / WK1)
KEGG Pathway
afl:Aflv_0425
EC number
6.1.1.4: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

736-805 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B7GK53

Entry ID Method Resolution Chain Position Source
AF-B7GK53-F1 Predicted AlphaFoldDB

No variants for B7GK53

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B7GK53

No associated diseases with B7GK53

5 regional properties for B7GK53

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 42 - 52 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 412 - 608 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 656 - 767 IPR013155
domain Methionyl/Leucyl tRNA synthetase 39 - 170 IPR015413
domain Leucyl-tRNA synthetase, editing domain 219 - 399 IPR025709

Functions

Description
EC Number 6.1.1.4 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
leucine-tRNA ligase activity Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu).

1 GO annotations of biological process

Name Definition
leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSFNHREIEK KWQKYWEENK TFKTTEDDGK RKFYALDMFP YPSGAGLHVG HPEGYTATDI
70 80 90 100 110 120
LARMKRMQGY NVLHPMGWDA FGLPAEQYAL DTGNDPAEFT EKNINNFRRQ IKSLGFSYDW
130 140 150 160 170 180
DREVNTTDPN YYKWTQWIFL KLYEKGLAYM DEVPVNWCPA LGTVLANEEV IDGKSERGGH
190 200 210 220 230 240
PVIRKPMKQW MLRITAYADR LLEDLEELDW PESIKEMQRN WIGRSEGANI HFQVDGHDET
250 260 270 280 290 300
FTVFTTRPDT LFGATYAVLA PEHPLVEKIT TPEQKEAVEA YLKQIQSKSD LERTDLAKEK
310 320 330 340 350 360
TGVFTGAYAI NPANGEKLPI WIADYVLMSY GTGAIMAVPA HDERDYEFAK KFNLPIKQVV
370 380 390 400 410 420
AGGDISKEAY TGDGEHINSD FLNGLNKEEA TKKMIEWLEA NGKGEKKVSY RLRDWLFSRQ
430 440 450 460 470 480
RYWGEPIPII HWEDGTMTPV PEEELPLVLP KTDEIKPSGT GESPLANIEE WVSVVDPKTG
490 500 510 520 530 540
KKGRRETNTM PQWAGSCWYY LRYIDPHNDK QLADPEKLEK WLPVDIYIGG AEHAVLHLLY
550 560 570 580 590 600
ARFWHKFLYD IGVVPTKEPF QKLFNQGMIL GENNEKMSKS KGNVVNPDDI VESHGADTLR
610 620 630 640 650 660
LYEMFMGPLE ASIAWSTKGL DGARRFLDRV WRLFVEENGE LNPKIVDNPE TDTLERVYHQ
670 680 690 700 710 720
TVKKVTEDYE ALRFNTAISQ LMVFINEAYK APILPKAYME GFVKLLSPVC PHIAEELWEK
730 740 750 760 770 780
LGYSNTIAYE AWPAYDEAKL VEDEVEIVIQ VNGKVRAKLH VPADATKEQL EQLAMEDEKI
790 800
KEQIEGKTVR KVIAVPGKLV NIVAN