B6YWK6
Gene name |
tyrS |
Protein name |
Tyrosine--tRNA ligase |
Names |
Tyrosyl-tRNA synthetase, TyrRS |
Species |
Thermococcus onnurineus (strain NA1) |
KEGG Pathway |
ton:TON_0981 |
EC number |
6.1.1.1: Ligases forming aminoacyl-tRNA and related compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B6YWK6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B6YWK6-F1 | Predicted | AlphaFoldDB |
No variants for B6YWK6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for B6YWK6 | |||||
No associated diseases with B6YWK6
1 regional properties for B6YWK6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Peptidase M28 | 129 - 317 | IPR007484 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.1.1.1 | Ligases forming aminoacyl-tRNA and related compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| tyrosine-tRNA ligase activity | Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| tyrosyl-tRNA aminoacylation | The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDIGRKIELI | TKRPTEELLT | VENLRHLLEI | GAPMQHYIGF | EISGYIHLGT | GLMAGAKIAD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LQKAGIKTRI | FLADWHSWIN | DKLGGDLEII | QKVALTYFKE | GMKQSIKVMG | GDPDKVEFVL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ASEILEKGDY | WQTVIDISKN | VTLARMMRSI | TIMGRQMGEA | IDFAKLIYPA | MQVADIFYQG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VTIAHAGMDQ | RKAHVIAIEV | AQKLKYHAIE | HNGEKLKPVA | LHHHLLLGLQ | EPPVWPIESE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EQYKELKTQM | KMSKSKPYSA | VFIHDTPEEI | KQKLRKAFCP | AREVKYNPVL | DWAEYIIFRE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EPTEFTIHRP | AKFGGDVTYT | TFEELKRDFA | EGKLHPLDLK | NAVAEYLIEL | LKPVRDYFEK |
| 370 | |||||
| HPEPLELMRE | IKITR |