B6YVS9

PR
Gene name
top6B
Protein name
Type 2 DNA topoisomerase 6 subunit B
Names
Type II DNA topoisomerase VI subunit B, TopoVI-B
Species
Thermococcus onnurineus (strain NA1)
KEGG Pathway
ton:TON_0764
EC number
5.6.2.2: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

193-268 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B6YVS9

Entry ID Method Resolution Chain Position Source
AF-B6YVS9-F1 Predicted AlphaFoldDB

No variants for B6YVS9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B6YVS9

No associated diseases with B6YVS9

10 regional properties for B6YVS9

Type Name Position InterPro Accession
domain DNA topoisomerase, type IA, domain 2 104 - 192 IPR003601
domain DNA topoisomerase, type IA, DNA-binding domain 242 - 508 IPR003602
domain TOPRIM domain 3 - 113 IPR006171
domain DNA topoisomerase, type IA, central 77 - 90 IPR013497-1
domain DNA topoisomerase, type IA, central 128 - 556 IPR013497-2
domain DNA topoisomerase, type IA, zn finger 574 - 611 IPR013498-1
domain DNA topoisomerase, type IA, zn finger 614 - 653 IPR013498-2
domain DNA topoisomerase, type IA, zn finger 655 - 688 IPR013498-3
active_site DNA topoisomerase, type IA, active site 279 - 302 IPR023406
domain DNA topoisomerase 1, TOPRIM domain 4 - 125 IPR034149

Functions

Description
EC Number 5.6.2.2 Enzymes altering nucleic acid conformation
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.

2 GO annotations of biological process

Name Definition
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
DNA unwinding involved in DNA replication The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAEASQLFKE FKIQSVSEFF RRNAAMLGYT GKIRSLTTVV HEAVTNSLDA CEEAGILPYV
70 80 90 100 110 120
RVEIEELGRE HYKVIVEDNG PGIPEKFITH VFGKMLAGTK AHRNIQSRGQ QGIGISGAVM
130 140 150 160 170 180
FAQITSGKAT RVITSTGGDI IEAWVKIDVD KNEGKIVKKE RHPNPKGWRG TRIELEVKNV
190 200 210 220 230 240
RYVRSKQGVY WYLKLTAIAN PHAHIELIEP DGKLIVFPRS SEEVPKPPVE MKPHPKGVLT
250 260 270 280 290 300
DDVYRMAKKT RRNTVRRFLI GEFSRISDKK VDELIKYIAA LRLIKTEKDK AVQDQLYERL
310 320 330 340 350 360
MNGEVDKVLR SFKGYTKVVK QVAKLMEKPP EKLSWHEAEE IVEAFKYMKF LAPPTHGLRP
370 380 390 400 410 420
IGEENIEKGL KGILKPEFVT AVTRPPKVYS GGIPFQVEVG LAYGGEISSG FDLLRYANRV
430 440 450 460 470 480
PLLFDAGSCV TTLAARSIDW KRYKVDDLER APVVLMINVI SVHVPYTGTG KQSIANVDEI
490 500 510 520 530 540
HNEIRLAIMD AARRLQTYLS GKHRRLYQVK RKKTFEKYVP EIAKALSILT GEPEEEVKNY
550 560
FLRFIEERFA QSEVEAEEVA ENA