B6IWP6

PR
Gene name
purC
Protein name
Phosphoribosylaminoimidazole-succinocarboxamide synthase
Names
SAICAR synthetase
Species
Rhodospirillum centenum (strain ATCC 51521 / SW)
KEGG Pathway
rce:RC1_3360
EC number
6.3.2.6: Acid--amino-acid ligases (peptide synthases)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

184-254 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B6IWP6

Entry ID Method Resolution Chain Position Source
AF-B6IWP6-F1 Predicted AlphaFoldDB

No variants for B6IWP6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B6IWP6

No associated diseases with B6IWP6

2 regional properties for B6IWP6

Type Name Position InterPro Accession
conserved_site SAICAR synthetase, conserved site 86 - 100 IPR018236
domain SAICAR synthetase/ADE2, N-terminal 4 - 238 IPR028923

Functions

Description
EC Number 6.3.2.6 Acid--amino-acid ligases (peptide synthases)
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate.

2 GO annotations of biological process

Name Definition
'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.
cobalamin biosynthetic process The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTRRRRIYEG KAKILFEGPE PGTLVQYFKD DATAFNAQKK GVITGKGVLN NRISEYLMMK
70 80 90 100 110 120
LGEIGIPTHF VRRLNMREQL IREVEIIPIE VVVRNVAAGS LTKRFGIPEG TQLPRSIVEY
130 140 150 160 170 180
YFKNDELGDP MVSEEHITAF GWAAPQDLDD MLALALRVND YLSGLFLGIG LRLVDFKVEF
190 200 210 220 230 240
GRLWENEEMR IILADEISPD NCRLWDVKTN EKLDKDRFRQ DLGNVAEAYQ EVAKRLGIMP
250
EAGPGDMKAP KLVQ