B6EMY6

PR
Gene name
ileS
Protein name
Isoleucine--tRNA ligase
Names
Isoleucyl-tRNA synthetase, IleRS
Species
Aliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238))
KEGG Pathway
vsa:VSAL_I0580
EC number
6.1.1.5: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

797-926 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B6EMY6

Entry ID Method Resolution Chain Position Source
AF-B6EMY6-F1 Predicted AlphaFoldDB

No variants for B6EMY6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B6EMY6

No associated diseases with B6EMY6

1 regional properties for B6EMY6

Type Name Position InterPro Accession
domain Major facilitator superfamily domain 2 - 390 IPR020846

Functions

Description
EC Number 6.1.1.5 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
isoleucine-tRNA ligase activity Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDYKETLNL PETGFPMRGN LANREPVMLK HWYDEDLYGE IRKAKKGKKS FILHDGPPYA
70 80 90 100 110 120
NGDIHIGHAL NKILKDIIIK SKTLSGFDAP YIPGWDCHGL PIELMVEKKK GKPGQKISAA
130 140 150 160 170 180
EFREECRKYA AVQVEGQKES FKRLGIMGEW DKPYRTMDFG TEANIIRSLG KIADQGHLLK
190 200 210 220 230 240
GFKPVHWCTD CGSALAEAEV EYQDKFSPSI DVRFVAADEA ATLAKFSTPE GHQGEGELSV
250 260 270 280 290 300
VIWTTTPWTL PANRAVALHA DLEYVLVQVE AHGEQKAERL ILASELAKSV MDRAGIEHFH
310 320 330 340 350 360
NLGFAKGSEL ELLQFNHPFY GFTVPAILGE HVTVDSGTGI VHTAPGHGQE DFVVGKKYDL
370 380 390 400 410 420
EIANPVGSNG VYLPDTELFA GQHVFKANDS VIDVLKEKGA LLHHHAIEHS YPHCWRHKTP
430 440 450 460 470 480
IIFRATPQWF ISMDQAGLRA KALEEVKSVE WMPEWGQSRI EGMIEGRPEW CISRQRTWGV
490 500 510 520 530 540
PIALFVHKET SELHPDSLEL IEKVAKLVEE KGIQAWWDLD IAELMGEDDA TKYEKVLDTL
550 560 570 580 590 600
DVWFDSGVTH FSVVDSREEY NFPQEERTHS ADLYLEGSDQ HRGWFQSSLI SSVAMKGKAP
610 620 630 640 650 660
YRQVLTHGFV VDGNGRKMSK SVGNVVAPKD VTNKLGADIL RLWVASTDYT NEVAVSDEIL
670 680 690 700 710 720
KRSADAYRRI RNTARFFLAN LNGFNPETDI VPAEEMVALD RWAVGRAFAA QEEIIKSYDE
730 740 750 760 770 780
YNLHEVTQRL MHFCSIEMGS FYLDVIKDRQ YTAKKSGHAQ RSCQTALYYI VEALVRWMAP
790 800 810 820 830 840
IMSFTADEIW NEMPGKRDKF VFTGEWYEGL FDLAEGEDLN NEFWSKIQAV RASVNKLLEA
850 860 870 880 890 900
ARGEKVIGGS LQAEITLYAD DALAAKINKL DNELRFVLLT SSATVKPLSE KSDSAKATEL
910 920 930 940 950
DGLFVDVAAS EAAKCERCWH HVADVGTIEG HEEVCGRCVS NVEGEGEERK FA