B5Z8L0

PR
Gene name
pnp
Protein name
Polyribonucleotide nucleotidyltransferase
Names
Polynucleotide phosphorylase, PNPase
Species
Helicobacter pylori (strain G27)
KEGG Pathway
hpg:HPG27_1159
EC number
2.7.7.8: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

361-435 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B5Z8L0

Entry ID Method Resolution Chain Position Source
AF-B5Z8L0-F1 Predicted AlphaFoldDB

No variants for B5Z8L0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B5Z8L0

No associated diseases with B5Z8L0

9 regional properties for B5Z8L0

Type Name Position InterPro Accession
domain Exoribonuclease, phosphorolytic domain 1 15 - 143 IPR001247-1
domain Exoribonuclease, phosphorolytic domain 1 325 - 457 IPR001247-2
domain S1 domain 620 - 691 IPR003029
domain K Homology domain 553 - 618 IPR004087
domain K Homology domain, type 1 558 - 615 IPR004088
domain Exoribonuclease, phosphorolytic domain 2 146 - 209 IPR015847-1
domain Exoribonuclease, phosphorolytic domain 2 460 - 529 IPR015847-2
domain Polyribonucleotide nucleotidyltransferase, RNA-binding domain 241 - 320 IPR015848
domain RNA-binding domain, S1 621 - 691 IPR022967

Functions

Description
EC Number 2.7.7.8 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
magnesium ion binding Binding to a magnesium (Mg) ion.
polyribonucleotide nucleotidyltransferase activity Catalysis of the reaction: RNA(n+1) + phosphate <=> RNA(n) + a nucleoside diphosphate.
RNA binding Binding to an RNA molecule or a portion thereof.

2 GO annotations of biological process

Name Definition
mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDFITINSSN KTEEFALKQV AKQATSSLMY RLGKTIILAS VCVEREPVSE DFLPLVVQFL
70 80 90 100 110 120
EKSYAAGKIP GGFVKREGRA QDFEILTSRL IDRTFRPLFP KDYRYPTQIT LMVLSHDIEN
130 140 150 160 170 180
DLQVSALNAA SVALFLAHIA PIKSVSACRI ARIDDEFIIN PNTSLLNQSS LDLFVSGTKE
190 200 210 220 230 240
SLNMIEMRSL GQKLNALEEP LMLKALELAQ KSLKETCTLY EEVFTPHQNE LLFKESQGII
250 260 270 280 290 300
FNERLLDLLK NQYFDEIIKG IESSALSERE NVFHEIAKKI SEAHSEFSLE EIEWSLEKVK
310 320 330 340 350 360
KTEIRRMIIQ DKIRPDKRAL EEVRPILIES DLLPMAHSSI LFTRGQTQSL VVGVLGTDND
370 380 390 400 410 420
AQTHESLEHK TPIKERFMFH YNFPPFCVGE ASSIGAASRR ELGHGNLAKR ALETSIKNKE
430 440 450 460 470 480
QVIRLVSEIL ESNGSSSMAS VCAGSLALYA SGVEIHDLVA GVAMGMVSEG QDYAILSDIS
490 500 510 520 530 540
GLEDAEGDMD FKIAGNLEGI TAMQMDTKMS GIQLEILYQA LLQAKEARKH ILKIMHEAKE
550 560 570 580 590 600
KIVINFSHLP TTEIFNVAPD KIVEIIGQGG RVIKEIVEKF EVKIDLNKPS GEVKIMGNKE
610 620 630 640 650 660
RVLKTKEFIL NYLHSLDQEL EQYTIDEVLE AQVKRIVDFG AFLSLPKGGE GLLRKQNMDR
670 680
CQVVLREGDS IRCRVISFNK GKIALDLA