B5YJY3

PR
Gene name
mutS
Protein name
DNA mismatch repair protein MutS
Names
Species
Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)
KEGG Pathway
tye:THEYE_A0706
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

764-852 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B5YJY3

Entry ID Method Resolution Chain Position Source
AF-B5YJY3-F1 Predicted AlphaFoldDB

No variants for B5YJY3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B5YJY3

No associated diseases with B5YJY3

5 regional properties for B5YJY3

Type Name Position InterPro Accession
domain DNA mismatch repair protein MutS, C-terminal 608 - 798 IPR000432
domain DNA mismatch repair protein MutS-like, N-terminal 9 - 118 IPR007695
domain DNA mismatch repair protein MutS, core 264 - 585 IPR007696
domain DNA mismatch repair protein MutS, connector domain 127 - 248 IPR007860
domain DNA mismatch repair protein MutS, clamp 422 - 512 IPR007861

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
damaged DNA binding Binding to damaged DNA.
double-stranded DNA binding Binding to double-stranded DNA.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

1 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEVSQEELTP LMRQYLRVKE QYKDAIVFFR LGDFYEMFGE DAVIASKILG ITLTSRDKSK
70 80 90 100 110 120
EKAIPMCGIP YFSADSYIEK LLREGYKVAI CEQIGDPKTS KGIVEREVIK VLTPGTYLPE
130 140 150 160 170 180
GVRENIYIMS IYPSKGKIGI ALADITTGQF FLYETDKNIT DEIERFEPKE ILIPASFEDS
190 200 210 220 230 240
LKFEISSYNK TFIEDWKFDY LLAYKTLLEH FKVASLKSYG AEEFSNAISA GGALLKYLEE
250 260 270 280 290 300
NKQQTEFKGI KILNLSEFML LDASTKKNLE IFVSLDGSRE GSLIWVLDET LTPMGARFLK
310 320 330 340 350 360
NTLSCPLLNI SEIEKRFDGI EAFCGDYLLR EKLEKILKDF PDIERIALKI KGKSINPKEL
370 380 390 400 410 420
NSLKNALKRI PELREVLRNK TEILNSLYNS LYELNELVTK IENALTENPP PVITEGGIFR
430 440 450 460 470 480
DGYNSTIDEL RALRTESKKY ILNMEAEERK KTGINSLKIG YNRVFGYYIE VTKPNLHLVP
490 500 510 520 530 540
SHYIRKQTLA NAERFITEEL KELELKIMSA EEKLKILEQE LFIELVNSIL PFTDKILNNG
550 560 570 580 590 600
ETIGFIDFLL SLAKVASKYN YVRPEINEED IIEIKDGRHP VIERLIQLGK LYEGRFIPND
610 620 630 640 650 660
LLIGPADQRI IILTGPNMAG KSTYMRQNAL IVLMAQIGSF VPAKYAKIGI VDRIFTRIGA
670 680 690 700 710 720
SDYLAKGQST FMVEMIETAN ILNNATPKSF IILDEVGRGT STFDGISIAW SVVEYIAEKI
730 740 750 760 770 780
KARTLFATHY HELTDLAFNL DCIKNFTVVV KEWGDEIIFL RKIQEGGADK SYGIQVARLA
790 800 810 820 830 840
GLPLEILNRA REILHRLEKK EFQVFPIRAR QLDLFFQGDP IKAELSKIDI DSLNPQKALK
850
KLKELKEMLK ND