B5YE42
Gene name |
mutL |
Protein name |
DNA mismatch repair protein MutL |
Names |
|
Species |
Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12) |
KEGG Pathway |
dth:DICTH_0942 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B5YE42
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B5YE42-F1 | Predicted | AlphaFoldDB |
No variants for B5YE42
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for B5YE42 | |||||
No associated diseases with B5YE42
6 regional properties for B5YE42
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Translational (tr)-type GTP-binding domain | 340 - 509 | IPR000795 |
| domain | Small GTP-binding protein domain | 343 - 499 | IPR005225 |
| domain | Translation initiation factor IF-2, N-terminal | 265 - 315 | IPR006847 |
| domain | Initiation factor 2 associated domain, bacterial | 61 - 95 | IPR013575 |
| domain | Translation initiation factor IF- 2, domain 3 | 617 - 730 | IPR023115 |
| domain | Translation initiation factor IF-2, domain II | 515 - 609 | IPR044145 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| mismatch repair complex | Any complex formed of proteins that act in mismatch repair. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| ATP-dependent DNA damage sensor activity | A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis. |
| mismatched DNA binding | Binding to a double-stranded DNA region containing one or more mismatches. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| mismatch repair | A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGKVVLLPEE | LRNKIAAGEV | VERPVSVVKE | LVENSIDAGA | TRIIVEFANG | GETLISVIDD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GEGMTREDAI | LALNRFATSK | IKTEEDLYNI | KTLGFRGEAL | ASIASVSKME | LRSKTELEDG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VFIKVEGGVI | KEVNLWQGSK | GTVIKVSDLF | YNVPARKKFL | KSKATETNLI | IDFVKRIAIA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YPQISFQLIQ | DGKSKFITPG | DGDLENLISL | LFDIRVQESL | ISFQKREGDY | CIEGFVSKPG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KLIALKSQDY | FYVNRRWVRN | NTILQAIREG | YKGRILDGYF | PFSIIFLTVP | YSEVDVNVHP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TKREVKFQKE | KEVYEFVFRS | IREALDEEEK | KFFINMKAPE | TESKEYKSDS | QITLDREILS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LPLEFKPYKS | EKKLSEAVSE | YIPLRSGFRI | VGQIFDNYII | LETKDKVYII | DQHAAHERIK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YEELKEELNL | GYIQNVEILF | PVVIEVSEEE | KILLDKYKDL | LERFAFSWED | FGPYHIRIVK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VPYEFLNFDS | KSIENLFREI | ISDISEKDLS | KLEDKIIKSM | ACHSAVRSGN | ILIREEMEML |
| 550 | 560 | 570 | |||
| IKLIFEKNIP | LTCPHGRPYI | WEISREDLER | YFHRR |